心脏死亡器官捐献时代肝移植后缺血型胆道病变的治疗和预防  

Treatment and prevention of ischemic-type biliary lesions after liver transplantation in the donation after cardiac death era

作　　者：张英才[1] 陈池 杨扬[1] Zhang Yingcai;Chen Chi;Yang Yang(Department of Hepatic Surgery and Liver Transplantation Center,the Third Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院肝脏外科肝移植中心,广州510630

出　　处：《中华消化外科杂志》2021年第10期1031-1036,共6页Chinese Journal of Digestive Surgery

基　　金：国家重点研发计划(2017YFA0104304);国家自然科学基金面上项目(81972286,81970567);广东省重点领域研发计划项目(2019B020236003);广东省自然科学基金(2018A030313043);浙江大学教育基金会树森·兰娟院士人才基金。

摘　　要：胆道并发症尤其是缺血型胆道病变(ITBL)是导致肝移植受者死亡和行再次肝移植的主要原因。近年来,由于心脏死亡供者供肝和脂肪变性供肝等边缘性供肝的临床应用,导致移植后ITBL发生率较高。肝移植后ITBL的治疗和预防成为研究热点。笔者结合国内外最新研究进展和其肝移植中心临床实践经验,深入探讨心脏死亡器官捐献时代肝移植后ITBL的治疗和预防策略。Biliary complications,especially the ischemic-type biliary lesions(ITBL),are the main causes of mortality and retransplantation for patients undergoing liver transplantation.In recent years,the application of marginal donor livers such as livers from donor of cardiac death and fatty liver leads to high incidence of ITBL.As a result,the treatment and prevention of ITBL after liver transplantation become a research hotspot.Based on the global research progress and the clinical experience of their liver transplantation center,the authors investigate the treatment and prevention of ITBL after liver transplantation in the donation after cardiac death era.

关 键 词：终末期肝病 肝移植 胆道并发症 缺血型胆道病变 非吻合口胆管狭窄 心脏死亡供器官 

分 类 号：R657.3[医药卫生—外科学]