新型冠状病毒病神经眼科表现的研究现状  

Reserch progress of neuro-ophthalmic manifestations of coronavirus disease 2019

作　　者：刘佩 宋沉生 吴松笛[1] Liu Pei;Song Chensheng;Wu Songdi(Department of Neurology and Neuro-ophthalmology,The First Hospital of Xi’an(The First Affiliated Hospital of Northwestern University),Xi’an 710002,China)

机构地区：[1]西安市第一医院(西北大学附属第一医院)神经内科和神经眼科,710002

出　　处：《中华眼底病杂志》2021年第10期812-817,共6页Chinese Journal of Ocular Fundus Diseases

基　　金：陕西省科技计划项目(2021SF-333);西安市科技计划项目(20YXYJ0008(1))。

摘　　要：始于2019年末的新型冠状病毒病(COVID-19)目前仍在世界范围内广泛流行,对全球的公共卫生造成巨大威胁。该病主要累及呼吸系统,还存在眼部及神经系统等肺外表现。由于神经眼科学表现的报道较少,尤其早期以眼部及神经眼科学症状为首发症状时,容易造成误诊并延误治疗。临床一线医生在初次接诊患者时,不仅需要询问发热、咳嗽、咽痛等呼吸系统表现,还需要问及复视、视力减退、眼球转动痛、步态异常或其他神经功能缺损的症状,因为这些肺外表现往往是严重感染的征象。了解COVID-19眼部症状、视觉传入障碍、视觉传出障碍及其可能的病因,对临床医生及早辨别和有效治疗COVID-19有着重要的临床价值。未来仍需更广泛的研究以证实COVID-19与神经眼科学疾病的因果关系,为全面了解COVID-19提供充分的依据。Currently,coronavirus disease 2019(COVID-19)is still widely prevalent around the world,leading to a major threat to the global public health.COVID-19 mainly involves the respiratory system,but extrapulmonary manifestations including that of the nervous system also exist in the setting of COVID-19.Misdiagnosis and delayed treatment of the disease may easily cause when ocular,especially neuro-ophthalmological symptoms are the first symptoms in early COVID-19,as the neuroophthalmological manifestations are rarely reported.First-line clinicians need to ask about not only respiratory symptoms such as fever,cough and sore throat,but also diplopia,impaired vision,eye motion pain,abnormal gait or other neurological deficits at the first reception,as these extrapulmonary manifestations are often signs of serious infection.The neuroophthalmological manifestations and possible underlying etiology of COVID-19 were summarized in this review,hoping to provide an early identification and effective treatment of COVID-19 for clinicians.More extensive studies are needed in the future to confirm the causal relationship between COVID-19 and neuroophthalmological disease to provide a sufficient basis for a comprehensive understanding of COVID-19.

关 键 词：新型冠状病毒病 严重急性呼吸综合征 神经眼科 综述 

分 类 号：R563.1[医药卫生—呼吸系统] R771.3[医药卫生—内科学]