羟苯磺酸钙胶囊联合大活络胶囊及丹红注射液在单纯型糖尿病视网膜病变患者中的疗效观察  

Combined therapy of calcium dobesilate capsules,oral administration of Dahuoluo capsules,and intravenous drip of Danhong injection in treatment of patients with nonproliferative diabetic retinopathy

作　　者：姚婷 万明 曾芳馨[2] Yao Ting;Wan Ming;Zeng Fangxin(Department of Endocrinology,the Second Affiliated Hospital of Chengdu Medical College(China National Nuclear Corporation 416 Hospital),Chengdu 610051,China;Department of Endocrinology and Rheumatism&Immunology,Dazhou Integrated TCM&Western Medicine Hospital,Dazhou 635000,China)

机构地区：[1]成都医学院第二附属医院·核工业四一六医院内分泌科,610051 [2]四川省达州市中西医结合医院内分泌风湿免疫科,达州635000

出　　处：《中华内分泌外科杂志》2021年第5期542-545,共4页Chinese Journal of Endocrine Surgery

摘　　要：目的探究单纯型糖尿病视网膜病变患者实施羟苯磺酸钙胶囊联合大活络胶囊及丹红注射液的效果。方法收集2019年1月至2019年12月在四川省达州市中西医结合医院就诊的106例单纯型糖尿病视网膜病变患者为研究对象,以随机数字表法分为对照组(单纯羟苯磺酸钙胶囊治疗)和干预组(羟苯磺酸钙胶囊联合大活络胶囊、丹红注射液治疗),各53例,对比治疗效果。结果治疗3个月后,两组患者的视力均明显改善(P<0.05),且干预组患者的视力高于对照组患者(P<0.05);两组患者视网膜中央动脉(CRA)和睫状后动脉(PCA)的收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)明显升高(P<0.05),RI明显降低(P<0.05),且干预组患者CRA和PCA的PSV和EDV明显高于对照组(P<0.05),RI明显低于对照组(P<0.05);干预组的治疗有效率为96.23%,显著高于对照组的79.25%(χ^(2)=7.102,P<0.05);干预组患者的不良反应发生率为9.43%,与对照组的3.78%无显著差异(χ^(2)=1.377,P>0.05),且给予针对性处理后,不良反应均消失。结论羟苯磺酸钙胶囊联合大活络胶囊及丹红注射液治疗单纯型糖尿病视网膜病变效果显著。Objective To investigate the combined therapy of calcium dobesilate capsules,oral administration of Dahuoluo capsules,and intravenous drip of Danhong injection in treatment of patients with nonproliferative diabetic retinopathy.Methods 106 cases were randomly selected from the patients with nonproliferative diabetic retinopathy admitted in Traditional Chinese and Western Hospital of Dazhou City from Jan.2019 to Dec.2019.Based on the random numbers table,the cases were divided into control group and intervention group,with each group 53 patients.They were respectively treated with the therapy of calcium dobesilate capsules alone and the combined therapy of calcium dobesilate capsules,oral administration of Dahuoluo capsules and intravenous drip of Danhong injection,and the therapeutic effects were compared.Results After treatment,the visual acuity of patients in both groups significantly improved(P<0.05),and the visual acuity of patients in the intervention group was higher than that of patients in the control group(P<0.05);after treatment,the peak systolic velocity(PSV)and end diastolic velocity(EDV)of the central retinal artery(CRA)and posterior ciliary artery(PCA)of the patients in both groups significantly increased(P<0.05),while RI significantly reduced(P<0.05),and PSV and EDV of CRA and PCA in the intervention group were significantly higher than those of the control group(P<0.05),while RI was significantly lower than that of the control group(P<0.05).After treatment,the therapeutic efficiency of the intervention group was 96.23%,significantly higher than 79.25%in the control group(χ^(2)=7.102,P<0.05).The incidence of adverse reactions in the intervention group was 9.43%,which had no significant difference with 3.78%in the control group(χ^(2)=1.377,P>0.05).After targeted treatment was given,the adverse reactions disappeared.Conclusion The combined therapy of calcium dobesilate capsules,oral administration of Dahuoluo capsules,and intravenous drip of Danhong injection was significantly effective in treatmen

关 键 词：糖尿病 单纯型视网膜病变 羟苯磺酸钙胶囊 丹红注射液 大活络胶囊 

分 类 号：R587.1[医药卫生—内分泌]