钠-葡萄糖共转运蛋白2抑制剂对心血管和肾脏作用机制研究进展  

Research progress of the mechanisms of sodium glucose co-transporter 2 inhibitor on the cardiovascular system and kidney

作　　者：王小楠 刘洪涛[2] 董占军[1,2] WANG Xiaonan;LIU Hongtao;DONG Zhanjun(Graduate School,Hebei Medical University,Shijiazhuang 050017,China;Department of Pharmacy,Hebei General Hospital,Shijiazhuang 050051,China)

机构地区：[1]河北医科大学研究生学院,石家庄050017 [2]河北省人民医院药学部,石家庄050051

出　　处：《药学服务与研究》2021年第5期370-373,共4页Pharmaceutical Care and Research

摘　　要：钠-葡萄糖共转运蛋白2抑制剂(sodium glucose co-transporter 2 inhibitor,SGLT2i)不仅可以降低血糖,还显示出心血管和肾脏保护作用。然而SGLT2i使心血管和肾脏获益的机制尚不明确,可能是多种机制共同作用的结果。SGLT2i可能通过改善血流动力学、抑制钠-氢交换器、改善心肌能量代谢方式、抑制心室重构、调节神经激素等方式,发挥心血管保护作用;通过管球反馈、调控肾脏能量代谢、抑制炎症反应、糖-盐-水效应、抑制缺氧诱导因子和钠-氢交换器等方式,发挥肾脏保护作用。本文总结了SGLT2i对心血管和肾脏的作用机制。Sodium glucose co-transporter 2 inhibitor(SGLT2i)could not only lower glucose level,but also exhibit cardiovascular and renal protection.However,the mechanism that cardiovascular and renal benefits of SGLT2i is still unclear,which might be the synergistic effects of various mechanisms.The cardiovascular protection of SGLT2i might be exerted through the access of improving hemodynamics,inhibiting sodium-hydrogen exchanger,improving myocardial energy metabolism,inhibiting ventricular remodeling as well as regulating neurohormones.Its renal protection might be activated by means of tubuloglomerular feedback,the regulation of renal energy metabolism,the inhibition of inflammatory response,the sugar-salt-water effect and the inhibition of hypoxia-inducible factor and sodium-hydrogen exchanger.The paper summarizes the related mechanisms of SGLT2i involving the cardiovascular system and kidney.

关 键 词：钠-葡萄糖共转运蛋白2抑制剂 心血管 肾脏 作用机制 综述 

分 类 号：R977.15[医药卫生—药品]