骨质疏松症与痴呆关系的研究进展  

Research progress in the relationship between osteoporosis and dementia

作　　者：范东伟[1] 陈仲强[1] Dong-wei Fan;Zhong-qiang Chen(Department of Orthopedics,Peking University Third Hospital,Beijing,100191,China)

机构地区：[1]北京大学第三医院骨科,北京100191

出　　处：《中国现代医学杂志》2021年第20期1-5,共5页China Journal of Modern Medicine

基　　金：国家自然科学基金(No:30801156,41931291)。

摘　　要：近年来研究显示骨质疏松症与痴呆密切相关。骨质疏松症人群痴呆发病风险高、发病率高;另一方面,痴呆人群骨质疏松症发病率高,发生骨质疏松性骨折风险大,致残、致死率高。骨质疏松症和痴呆在危害患者健康的同时,也给照护家庭及社会带来很大负担,成为世界范围内的慢性病研究热点问题。该文对骨质疏松症与痴呆关系的研究进展进行综述,重点讨论痴呆对骨质疏松症及骨质疏松性骨折的影响,也对相关骨-脑轴的病理生理机制进行综述,希望能为骨质疏松症伴痴呆的研究提供新思路。Recent studies have shown that osteoporosis is closely related to dementia.On the one hand,individuals with osteoporosis exhibit a high risk of dementia and the incidence of dementia is especially high among them.On the other hand,a high frequency of osteoporosis is observed in dementia and therefore high disability and fatality rates are present due to an increased risk of osteoporotic fracture.While endangering the health of patients,osteoporosis and dementia also bring a great burden to families and the society,and have become a hot issue in the field of chronic disease research worldwide.This article reviews the progress in the relationship between osteoporosis and dementia by focusing on the impact of dementia on osteoporosis and osteoporotic fracture and the pathophysiology of related bone-brain axis,aiming to provide novel ideas for the future research of osteoporosis with dementia.

关 键 词：骨质疏松症 痴呆 骨质疏松性骨折 骨-脑轴 

分 类 号：R580[医药卫生—内分泌] R749.16[医药卫生—内科学]