桃红四物汤联合单侧经皮穿刺椎体成形术治疗老年骨质疏松性椎体压缩性骨折的临床研究  

Efficacy of Taohong Siwu Decoction combined with unilateral percutaneous vertebroplasty in the treatment of elderly patients with OVCF

作　　者：王志刚[1] 刘沛[2] Zhi-gang Wang;Pei Liu(Department of Geriatrics,Wuhan,Hubei 430022,China;Department of Orthopedics,Wuhan First Hospital,Wuhan,Hubei 430022,China)

机构地区：[1]武汉市第一医院老年病科,湖北武汉430022 [2]武汉市第一医院骨科,湖北武汉430022

出　　处：《中国现代医学杂志》2021年第20期24-29,共6页China Journal of Modern Medicine

基　　金：武汉市医学科研项目(No:WX20024)。

摘　　要：目的评估桃红四物汤联合单侧经皮穿刺椎体成形术(PVP)治疗老年骨质疏松性椎体压缩性骨折(OVCF)的疗效。方法选取2019年6月—2021年6月就诊于武汉市第一医院的老年OVCF患者142例作为研究对象。按随机对照原则分为研究组和观察组。两组均接受单侧PVP术,研究组术后当天接受桃红四物汤治疗。对比两组综合疗效、伤椎高度、Cobb角、骨密度、骨代谢指标、骨再生指标、疼痛程度、功能障碍程度。结果研究组总优良率比对照组高(P<0.05)。研究组伤椎高度、L_(1)~L_(4)骨密度及股骨近端骨密度的差值大于对照组(P<0.05),Cobb角减小的幅度大于对照组(P<0.05)。研究组BALP、OC、tPⅠNP的差值大于对照组(P<0.05),β-CTX降低的幅度大于对照组(P<0.05)。研究组手术前后骨再生指标的差值大于对照组(P<0.05)。研究组手术前后VAS评分、ODI指数的差值下降幅度大于对照组(P<0.05)。结论桃红四物汤可促进老年OVCF患者单侧PVP术后骨折愈合,减轻疼痛及功能障碍程度,改善骨密度,调节成骨细胞及破骨细胞活性。Objective To evaluate the clinical effect of Taohong Siwu Decoction combined with unilateral percutaneous vertebroplasty(PVP)in the treatment of osteoporotic vertebral compression fractures(OVCF)in the elderly.Methods A total of 142 elderly patients with OVCF who were admitted to Wuhan First Hospital from June 2019 to June 2021 were selected and grouped randomly into study group and control group.Both groups received unilateral PVP surgery,and the study group also received Taohong Siwu Decoction treatment on the same day as the operation.The comprehensive efficacy,level of injured vertebrae,Cobb angle,bone mineral density,bone metabolism indexes,bone regeneration indexes,and degree of pain and dysfunction were compared between the two groups.Results The total excellent and good rate of the study group was higher than that of the control group(P<0.05).The differences of the level of injured vertebrae before and after the treatment were greater in the study group relative to the control group(P<0.05).The bone mineral density of L_(1)-L_(4) and proximal femur in the study group was higher than that in the control group(P<0.05).The change of in the study group was greater than that in the control group(P<0.05).The differences of serum levels of BALP,OC,tPⅠNP andβ-CTX before and after the treatment were higher compared with the control group(P<0.05).Besides,the differences of bone regeneration indexes,VAS score,and ODI before and after the treatment in the study group were significantly higher than those in the control group(P<0.05).Conclusions Taohong Siwu Decoction can promote fracture healing,alleviate pain and dysfunction,improve bone mineral density,and regulate the activity of osteoblasts and osteoclasts in elderly patients undergoing unilateral PVP.

关 键 词：骨质疏松症 骨折 老年人 经皮椎体成形术 桃红四物汤 

分 类 号：R683.2[医药卫生—骨科学]