水杨醛缩2-肼咪唑希夫碱的合成、晶体结构及其与DNA作用的光谱研究  

Synthesis,Crystal Structure of Salicylaldehyde-Condensed 2-Hydrazinoimidazole Schiff Base and Spectrum Study of Its Interaction with DNA

作　　者：钟雨佳 黄如川 仇继家 覃姣兰 袁涛 Zhong Yujia;Huang Ruchuan;Qiu Jijia;Qin Jiaolan;Yuan Tao(Key Laboratory of Regional Ecological Environment Analysis and Pollution Control of West Guangxi,College of Chemical and Environmental Engineering,Baise University,Baise 533000,China)

机构地区：[1]百色学院化学与环境工程学院桂西区域生态环境分析和污染控制重点实验室,广西百色533000

出　　处：《山东化工》2021年第19期1-3,共3页Shandong Chemical Industry

基　　金：广西高校中青年教师基础能力提升项目(2017ky1277);国家级大学生创新创业训练计划项目(希夫碱铂金属配合物的合成、表征及其与生物大分子作用的光谱研究:201910609028;希夫碱稀土配合物的合成、表征及其与生物大分子作用的光谱研究:202010609011)。

摘　　要：希夫碱及其金属配合物因具有显著的抗菌、抗癌、抗病毒生物活性,在分析化学、生物化学、光电技术等众多领域中应用广泛。本文利用2-肼咪唑啉溴酸盐和水杨醛反应,得到希夫碱(L),通过X-射线单晶衍射确定L是正交晶系,Aba2点群,并利用紫外-可见吸收光谱和荧光光谱研究L与ct-DNA的相互作用方式,结果表明L与ct-DNA有微弱的插入作用。Schiff bases and their metal complexes are widely used in analytical chemistry,biochemistry,photoelectric technology and many other fields because of their remarkable antibacterial,anticancer and antiviral biological activities.In this paper,Schiff base(L)was obtained by the reaction of 2-hydrazinimidazole and salicylaldehyde.The crystal of L was determined to be orthorhombic by X-ray single crystal diffraction.The interaction between L and ct-DNA was studied by UV-Vis absorption spectrum and fluorescence spectrum.The results showed that L had weak intercalation with ct-DNA.

关 键 词：希夫碱 晶体结构 CT-DNA 插入作用 

分 类 号：O641.4[理学—物理化学]