小剂量阿司匹林联合低分子肝素钙、黄体酮、地屈孕酮治疗复发性流产伴高同型半胱氨酸血症的效果分析  

Analysis of the effect of low-dose aspirin combined with low-molecular-weight heparin calcium,progesterone and dydrogesterone in the treatment of recurrent abortion with hyperhomocysteinemia

作　　者：王春玲 WANG Chun-ling(Xingcheng Women’s and Children’s Hospital,Xingcheng 125100,China)

机构地区：[1]兴城市妇女儿童医院,125100

出　　处：《中国现代药物应用》2021年第19期23-25,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析小剂量阿司匹林联合低分子肝素钙、黄体酮、地屈孕酮治疗复发性流产伴高同型半胱氨酸血症的疗效。方法62例复发性流产伴高同型半胱氨酸血症患者,采用随机数字表法分为对照组和观察组,每组31例。两组均应用叶酸及甲钴胺治疗高同型半胱氨酸血症,在此基础上,对照组应用黄体酮联合地屈孕酮治疗,观察组应用小剂量阿司匹林联合低分子肝素钙、黄体酮、地屈孕酮治疗。比较两组患者妊娠结局、妊娠并发症发生情况、不良反应发生情况。结果观察组胎儿总活产率为93.5%,明显高于对照组的67.7%,差异具有统计学意义(P<0.05)。观察组患者妊娠并发症发生率为12.9%,明显低于对照组的35.5%,差异具有统计学意义(P<0.05)。观察组患者不良反应发生率为12.9%,与对照组的22.6%比较差异无统计学意义(P>0.05)。结论对复发性流产伴高同型半胱氨酸血症患者应用小剂量阿司匹林联合低分子肝素钙、黄体酮、地屈孕酮治疗可取得较好的临床保胎效果,且不良反应较少。Objective To analyze the efficacy of low-dose aspirin combined with low-molecularweight heparin calcium,progesterone and dydrogesterone in the treatment of recurrent abortion with hyperhomocysteinemia.Methods A total of 62 cases of recurrent abortion with hyperhomocysteinemia were divided into control group and observation group according to random numerical table,with 31 cases in each group.Both groups were treated with folic acid and methylcobalamin for hyperhomocysteinemia.On this basis,the control group was treated with progesterone and dydrogesterone,and the observation group was treated with lowdose aspirin,low-molecular-weight heparin calcium,progesterone and dydrogesterone.The pregnancy outcome,pregnancy complications,and occurrence of adverse reactions were compared between the two groups.Results The total live birth rate of the fetus was 93.5%in the observation group,which was significantly higher than 67.7%in the control group,and the difference was statistically significant(P<0.05).The incidence of pregnancy complications was 12.9%in the observation group,which was significantly lower than 35.5%in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the observation group was 12.9%,which was not statistically different from 22.6%in the control group(P>0.05).Conclusion The application of low-dose aspirin combined with low-molecular-weight heparin calcium,progesterone,and dydrogesterone tablets in patients with recurrent miscarriage and hyperhomocysteinemia can achieve better clinical fetal protection effects with fewer adverse reactions.

关 键 词：复发性流产 高同型半胱氨酸血症 阿司匹林 低分子肝素 地屈孕酮 

分 类 号：R714.21[医药卫生—妇产科学]