广东省部队入伍新兵接种国产麻腮风疫苗的安全性及影响因素  

Safety and influencing factors of domestic measles-mumps-rubella combined vaccine among new recruits in Guangdong province

作　　者：谢晓波 于德宪 刘文毅 杨阳 XIE Xiao-bo;YU De-xian;LIU Wen-yi;YANG Yang(Center for Disease Control and Prevention of Southern Theatre Command,Guangzhou,Guangdong 510507,China)

机构地区：[1]南部战区疾病预防控制中心,广东广州510507

出　　处：《热带医学杂志》2021年第9期1218-1221,共4页Journal of Tropical Medicine

基　　金：广东省医学科学技术研究基金(A2018496)。

摘　　要：目的探讨部队入伍新兵接种国产麻腮风疫苗(MMR)的安全性及影响因素。方法选择驻广东部队17~24岁的新兵作为研究对象,观察接种1剂次MMR 3d内不良反应的发生情况。结果新兵接种国产麻腮风疫苗不良反应总发生率为5.81%(115/1979),其中局部反应和全身反应发生率分别为1.67%和4.75%,所有反应均为一过性反应;局部反应均为接种当天出现,3d内消失,全身反应73.40%在第1天出现,76.92%在3d内消失。影响因素分析发现,出现局部反应和全身反应没有明确关联性,吸烟的新兵比不吸烟的新兵更容易发生不良反应(χ^(2)=13.31,P<0.01,OR=2.09)。结论国产MMR在新兵中接种具有良好的安全性;吸烟是接种不良反应发生的可疑危险因素。Objective To evacuate the safety of domestic measles-mumps-rubella combined vaccine(MMR),and explore its influencing factors.Method The 17-24 year old new recruits from army in Guangdong were selected as subjects to observe the occurrence of adverse effects within 3 days after 1 dose of MMR.Results The overall incidence of adverse effects was 5.81%(115/1979),including local reactions(1.67%)and systemic reactions(4.75%).All reactions were transient.Local reactions occurred on the day of inoculation and disappeared within 3 days.73.40%of systemic reactions occurred on the first day and 76.92%disappeared within 3 days.The analysis of influencing factors showed that there was no clear correlation between local response and systemic response,and those who smoked were more likely to have adverse effects than those who did not smoke(χ^(2)=13.31,P<0.01,OR=2.09).Conclusions Domestic MMR had good safety when inoculated in new recruits.Smoking might be a suspected risk factor for adverse effects of vaccination.

关 键 词：新兵 麻腮风疫苗 安全性 影响因素 

分 类 号：R511.1[医药卫生—内科学] R511.2[医药卫生—临床医学]