重组火鸡疱疹病毒疫苗研制现状  

The status in the research of Herpesvirus of turkey-based vaccine

作　　者：李文桂[1] 陈雅棠[1] LI Wen-gui;CHEN Ya-tang(Institute of Infectious and Parasitic Diseases,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院传染病寄生虫病研究所,重庆400016

出　　处：《热带医学杂志》2021年第9期1222-1226,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金(30801052,30671835,30500423,30200239)。

摘　　要：火鸡疱疹病毒(HVT)是一种预防马立克氏病的常规异源疫苗。该病毒可刺激感染的宿主产生细胞、体液和粘膜免疫应答,是一种有希望的疫苗载体,可表达病毒、细菌和寄生虫的多种蛋白。以HVT为载体的疫苗包括:禽流感病毒(rHVT-HA/NA)、新城疫病毒(rHVT-HA/NA/F)、传染性法氏囊病毒(rHVT-VP2)、传染性喉气管炎病毒(rHVT-gB/gD/gI)、马立克氏病病毒(rHVT-gB)、鸡传染性贫血病毒(rHVT-VP1/VP2)、鹦鹉热衣原体(rHVT-PmpD-N)和堆型艾美球虫(rHVT-EalA)等,本文将综述这些HVT病毒介导的疫苗的研制现状。Herpesvirus of turkey(HVT)is one type of routine heterologous vaccine to control Marek’s disease;it may stimulate cellular,humoral and mucosal immune responses in the host,and may be regarded as a desirable vaccine vector for displaying many proteins of viruses,bacteria,and parasites.These HVT-based vaccines include Avian influence virus(rHVT-HA/NA),Newcastle disease virus(rHVT-HA/NA/F),Infectious bursal disease virus(rHVT-VP2),Infectious laryngotracheitis virus(rHVT-gB/gD/gI),Marek’s disease virus(rHVT-gB),Chicken infectious anemia virus(rHVT-VP1/VP2),Chlamydia psittaci(rHVT-PmpD-N),and Eimeria acervulina(rHVT-EalA).The review outlines the status in the research of HVT-based vaccines.

关 键 词：火鸡疱疹病毒 病毒 细菌 寄生虫 疫苗 

分 类 号：S852.65[农业科学—基础兽医学] R392.11[农业科学—兽医学]