加强管理对氨酚羟考酮片处方用药的影响分析  

Analysis of the Influence of Strengthening Management on the Prescription of Oxycodone and Acetaminophen Tablets

作　　者：田如新 韩俊萍 张行飞 康龙 张湛 覃旺军[4] TIAN Ru-xin;HAN Jun-ping;ZHANG Xing-fei;KANG Long;ZHANG Zhan;QIN Wang-jun(Department of Pharmacy,Beijing Hospital Traditional Chinese Medicine,Beijing 101300,China;Department of Pharmacy,the Second Affiliated Hospital of Soochow University,Suzhou 215000,China;Research Center for Clinical Trial of the Third Xiangya Hospital of Central South University,Changsha 410000,China;Department of Pharmacy,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]北京中医医院顺义医院药学部,北京101300 [2]苏州大学附属第二医院药剂科,苏州215000 [3]中南大学湘雅三医院临床试验研究中心,长沙410000 [4]中日友好医院药学部,北京100029

出　　处：《中国合理用药探索》2021年第10期32-35,共4页Chinese Journal of Rational Drug Use

基　　金：中央高校基本科研业务费专项资金资助项目(3332020075)。

摘　　要：目的:通过对比分析本院根据《国家药监局国家卫生健康委关于加强氨酚羟考酮片管理的通知》要求对氨酚羟考酮片加强管理前后的门急诊处方,评价加强管理对氨酚羟考酮片滥用风险的影响。方法:通过医院药学服务系统,选取本院加强管理前4个月(2019年5月1日~2019年8月31日)的531张氨酚羟考酮片门急诊处方作为对照组,选取本院加强管理后4个月(2019年12月1日~2020年3月31日)的496张氨酚羟考酮片门急诊处方作为观察组。采用回顾性研究方法,分析加强管理前后4个月的氨酚羟考酮片处方情况,使用SPSS 22.0统计学软件分析处理数据。结果:观察组为第二类精神药品专用处方,对照组为普通处方;观察组联合用药占比(0.20%)低于对照组(57.25%,P<0.05);观察组平均单次给药量(5.41 mg)低于对照组(6.25 mg,P<0.05);观察组平均日剂量(14.36 mg)低于对照组(15.78 mg,P<0.05);观察组超过每日最大剂量的处方占比(0.40%)低于对照组(1.88%,P<0.05);观察组平均每张处方发药量(1.93盒)低于对照组(3.05盒,P<0.05)。结论:加强管理后,氨酚羟考酮片处方管理级别升高,联合用药、单次给药量、日剂量、单张处方发药量减少,药物滥用的风险降低。Objective:To compare and analyze the prescriptions of oxycodone and acetaminophen tablets in outpatient and emergency departments before and after the strengthening management according to Notice of National Medical Products Administration and National Health Commission of the People s Republic of China on Strengthening Management of Oxycodone and Acetaminophen Tablets,and to evaluate the effect of strengthening management on the risk of abuse of oxycodone and acetaminophen tablets.Methods:Through the hospital pharmaceutical care system,a total of 531 outpatient and emergency prescriptions of oxycodone and acetaminophen tablets in 4 months before strengthening management(from May 1,2019 to August 31,2019)in our hospital were selected as control group;and a total of 496 outpatient and emergency prescriptions of oxycodone and acetaminophen tablets in 4 months after strengthening management(from December 1,2019 to March 31,2020)in our hospital were selected as observation group.The prescription of oxycodone and acetaminophen tablets in 4 months before and after strengthening management was analyzed by retrospective research method,and the data were analyzed and processed by SPSS 22.0 statistical software.Results:The observation group was the special prescription for classⅡpsychotropic drugs,and the control group was the general prescription.The proportion of combined medication in observation group(0.20%)was lower than that of the control group(57.25%,P<0.05).The average single dose in observation group(5.41 mg)was lower than that in control group(6.25 mg,P<0.05).The average daily dose of observation group(14.36 mg)was lower than that of control group(15.78 mg,P<0.05).The proportion of prescriptions exceeding daily maximum dose in observation group(0.40%)was lower than that in control group(1.88%,P<0.05).The average dose per prescription in the observation group(1.93 boxes)was lower than that in the control group(3.05 boxes,P<0.05).Conclusion:After strengthening management,the prescription management level of oxyc

关 键 词：氨酚羟考酮 药物滥用 加强管理 联合用药 给药量 

分 类 号：R917[医药卫生—药物分析学]