Dendrimer-based Hydrogels with Controlled Drug Delivery Property for Tissue Adhesion  

作　　者：Ya-Qiang Wang Xue-Yu Dou Hu-Fei Wang Xing Wang De-Cheng Wu 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,State Key Laboratory of Polymer Physics&Chemistry,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [2]University of Chinese Academy of Sciences,Beijing 100049,China [3]Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen 518055,China

出　　处：《Chinese Journal of Polymer Science》2021年第11期1421-1430,共10页高分子科学（英文版）

基　　金：financially supported by the Ministry of Science and Technology of China(No.2020YFA0908900);the National Natural Science Foundation of China(Nos.21935011,51973226,21725403 and 81871782);the Youth Innovation Promotion Association CAS(No.2019031)。

摘　　要：In recent years,the hydrogel-based tissue adhesives have been extensively investigated for their excellent biocompatibility and the ability to be administered directly within the adherent tissue.To meet the requirement for more controllable release in various physiological settings,the components of hydrogel adhesive should be more precisely tailored.In this work,the POSS-ace-PEG hydrogel adhesive was fabricated with the polyacetal dendrimer G1’-[NH3 Cl]16 and poly(ethylene glycol)succinimidyl carbonate(PEG-SC)due to the regular peripheral amino structure of G1’-[NH3 Cl]16.Rheological and adhesion tests demonstrated that the hydrogel adhesive had good mechanical and adhesive properties,which could effectively adhere to the pigskin and severed nerves.Moreover,the tissue adhesive exhibited good stability under neutral conditions and the rapid degradation under acidic conditions,allowing for the release of doxycycline hydrochloride(DOX)drug in response to pH.Together,these results suggested that the POSS-ace-PEG adhesive had the potential to provide an alternative to tissue adhesives for applications in pathological environments(inflammation,tumors,etc.).

关 键 词：Hydrogel adhesive DENDRIMER PH-RESPONSIVE Drug delivery Tissue adhesion 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]