帕罗西汀联合文拉法辛对产后抑郁症患者抑郁程度、睡眠质量及生活质量的影响研究  

Effects of Paroxetine Combined with Venlafaxine on Degree of Depression,Sleep Quality and Quality of Life in Patients with Post-partum Depression

作　　者：司军英[1] 杨艺全[2] 杨晓萍[3] 李薇[3] 赵书珍 杨习英 SI Junying;YANG Yiquan;YANG Xiaoping;LI Wei;ZHAO Shuzhen;YANG Xiying(Department of Obstetrics,Handan Central Hospital,Handan 056000,China;Department of Otolaryngology,the Third Hospital of Handan,Handan 056000,China;Department of Obstetrics and Gynecology,Jizhong Energy Fengfeng Group Co.,Ltd.General Hospital,Handan 056000,China;Institute of Science and Technology,Hebei University of Engineering,Handan 056038,China)

机构地区：[1]河北省邯郸市中心医院产二科,056000 [2]河北省邯郸市第三医院耳鼻喉科,056000 [3]冀中能源峰峰集团有限公司总医院妇产科,河北省邯郸市056000 [4]河北工程大学科学技术研究院,河北省邯郸市056038

出　　处：《实用心脑肺血管病杂志》2021年第10期101-105,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：邯郸市科技局计划项目(1823208015ZC)。

摘　　要：背景相关数据显示,近年来产后抑郁症发病率高达15%~30%,且抑郁症会导致产妇丧失看护婴儿的能力,严重者甚至发生恶性事件。因此,产后抑郁症的治疗也越来越引起临床医生的关注。目的探讨帕罗西汀联合文拉法辛对产后抑郁症患者抑郁程度、睡眠质量及生活质量的影响。方法选取2018年7月至2020年1月邯郸市中心医院收治的产后抑郁症患者96例,按照治疗方法不同分为对照组1组、对照组2组及研究组,每组32例。对照1组患者采用帕罗西汀治疗,对照2组患者采用文拉法辛治疗,研究组患者采用帕罗西汀联合文拉法辛治疗,三组患者均治疗8周。比较三组患者治疗前及治疗8周后爱丁堡产后抑郁量表(EPDS)评分,治疗8周后匹兹堡睡眠质量指数(PSQI)评分,治疗前及治疗8周后健康状况调查问卷(SF-36)评分,治疗期间不良反应发生情况。结果治疗8周后,研究组患者情感缺失、焦虑、抑郁评分及EPDS总分低于对照1组和对照2组(P<0.05)。治疗8周后,研究组患者入睡时间、睡眠效率、日间功能障碍、主观睡眠质量评分低于对照1组和对照2组(P<0.05)。治疗8周后,研究组患者社会功能、躯体功能、角色功能、认知功能评分高于对照1组、对照2组(P<0.05)。三组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论与单用帕罗西汀、文拉法辛相比,帕罗西汀联合文拉法辛能更有效地减轻产后抑郁症患者抑郁程度,改善患者睡眠质量及生活质量,且未增加不良反应发生风险。Background Relevant data show that incidence of post-partum depression is as high as 15%-30%in recent years,and depression can lead to maternal loss of the ability to care for infants,and even cause serious cases of malignant events.Therefore,the treatment of post-partum depression has attracted more and more attention of clinicians.Objective To investigate the effects of paroxetine combined with venlafaxine on degree of depression,sleep quality and quality of life in patients with post-partum depression.Methods A total of 96 patients with post-partum depression treated in Handan Central Hospital from July 2018 to January 2020 were selected and divided into control group 1,control group 2 and study group according to different treatment methods,with 32 cases in each group.Patients in control group 1 were treated with paroxetine,patients in control group 2 were treated with venlafaxine,and patients in study group were treated with paroxetine combined with venlafaxine.All three groups were treated for 8 weeks.The scores of Edinburgh Postpartum Depression Scale(EPDS)before treatment and after 8 weeks of treatment,Pittsburgh Sleep Quality Index(PSQI)after 8 weeks of treatment,36-Item Short-form(SF-36)before treatment and after 8 weeks of treatment and incidence of adverse reactions during treatment were compared among the three groups.Results After 8 weeks of treatment,the scores of affective deficit,anxiety,depression and EPDS total score in the study group were lower than those in the control group 1 and the control group 2(P<0.05).After 8 weeks of treatment,the scores of sleep time,sleep efficiency,daytime dysfunction and subjective sleep quality of the study group were lower than those of the control group 1 and the control group 2(P<0.05).After 8 weeks of treatment,the scores of social function,physical function,role function and cognitive function in the study group were higher than those in the control group 1 and the control group 2(P<0.05).There was no significant difference in the incidence of adverse react

关 键 词：产后抑郁症 帕罗西汀 文拉法辛 生活质量 睡眠质量 

分 类 号：R714.46[医药卫生—妇产科学]