FDPS、LRP5基因多态性与绝经后妇女骨质疏松的关系  

Relationship between gene polymorphisms of FDPS and LRP5 and the osteoporosis in postmenopausal women

作　　者：刘百奇[1] 车德馨[1] 侯庆露[1] 韩健 潘华兴[1] 徐东辉[1] LIU Baiqi;CHE Dexin;HOU Qinglu;HAN Jian;PAN Huaxing;XU Donghui(Department of Orthopedics, Qiqihar First Hospital, Qiqihar 161005)

机构地区：[1]齐齐哈尔市第一医院骨外科,黑龙江齐齐哈尔161005

出　　处：《中国骨质疏松杂志》2021年第10期1438-1442,共5页Chinese Journal of Osteoporosis

摘　　要：目的探讨FDPS、LRP5基因多态性与绝经后妇女骨质疏松的关系。方法在2017年6月至2019年8月期间,共纳入364名绝经后妇女,其中228名确诊为骨质疏松症(OP),为骨质疏松组,另136名骨质正常者为对照组。收集所有参与者的临床数据和血液样本,分别采用TaqMan荧光探针及限制性片段长度多态性(PCR-RELP)法对FDPS rs2297480、LRP5 rs3736228位点进行基因分型,统计其与骨密度(BMD)和骨质疏松的关系。结果FDPS rs2297480 TT基因型腰椎和全髋关节的BMD值明显较低,T等位基因的存在与骨质疏松症有显著相关性。LRP5 rs3736228携带CC基因型的股骨颈和全髋关节骨密度值较低。结论在绝经后的骨质疏松症妇女中,BMD和FDPS基因多态性之间有很强的相关性,与LRP5基因多态性之间存在较低的关连。Objective To discuss the relationship between gene polymorphism of FDPS and LRP5 and the osteoporosis in postmenopausal women.Methods From June 2017 to August 2019,364 postmenopausal women were divided into the osteoporosis group(228 patients)and the normal group(136 patients).Clinical data and blood samples were collected from all the participants,the genetic polymorphism of FDPS rs2297480 and LRP5 rs3736228 were evaluated with the method of TaqMan fluorescent probe and restriction fragment length polymorphism(PCR-RELP).Analysis of relationship of genetic polymorphism with bone mineral density(BMD)and osteoporosis.Results The BMD values of lumbar spine and total hip joint in FDPS RS2297480 TT genotype patients were significantly lower,and the presence of T alleles was significantly correlated with osteoporosis.The BMD values of femoral neck and total hip joint in LRP5 rs3736228 patients with CC genotype were lower.Conclusion In postmenopausal women with osteoporosis,there is a strong correlation between BMD values and FDPS gene polymorphisms and a low correlation with LRP5 gene polymorphisms.

关 键 词：绝经后妇女 骨质疏松症 FDPS LRP5 

分 类 号：R589.5[医药卫生—内分泌]