基于温度响应的生物相容性聚乙二醇单甲醚-马来松香酸聚酯合成及其可逆的形态转变  

Synthesis of Thermo-sensitive and Biocompatible Polyethylene Glycol Monomethyl Ether-Maleic Acid Polyester and Its Reversible Morphological Transition

作　　者：亓坤 邹梦君 廖华珍 赵彦芝 雷福厚 周菊英 QI Kun;ZOU Mengjun;LIAO Huazhen;ZHAO Yanzhi;LEI Fuhou;ZHOU Juying(School of Chemistry and Chemical Engineering,Guangxi University for Nationalities,Nanning 530006,China;Key Laboratory of Chemistry and Engineering of Forest Products,State Ethnic Affairs Commission,Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products,Nanning 530006,China)

机构地区：[1]广西民族大学化学化工学院,南宁530006 [2]林产化学与工程国家民委重点实验室,广西林产化学与工程重点实验室/协同创新中心,南宁530006

出　　处：《西南大学学报（自然科学版）》2021年第11期93-101,共9页Journal of Southwest University(Natural Science Edition)

基　　金：广西科技基地和人才专项(AD18126005);广西民族大学实验技术创新与实验室管理研究项目(2019MDSY018);广西民族大学研究生教育创新计划项目(gxun-chxps201917,gxun-chxzs2019010).

摘　　要：通过催化酯化法制备了聚乙二醇单甲醚马来松香酸聚酯.利用红外、核磁、紫外和GPC等技术研究了聚乙二醇单甲醚马来松香酸聚酯的结构与分子量.聚乙二醇单甲醚马来松香酸聚酯无毒且具备较好的热稳定性,其溶液在升温过程中聚集成胶束且尺寸逐渐增大,到达转折温度后聚集体的尺寸又逐渐变小,这种聚集与紧缩形态转变的过程具有可逆性.聚乙二醇单甲醚马来松香酸聚酯胶束的形成为温敏性载体及绿色表面活性剂的设计开发了新思路.Polyethylene glycol monomethyl ether-maleic acid polyester was prepared with the catalytic esterification method.The structure and molecular weight of polyethylene glycol monomethyl ether-maleic acid polyester were studied with infrared,nuclear magnetic,ultraviolet,GPC and other technologies.Polyethylene glycol monomethyl ether-maleic acid rosin acid polyester was found to be non-toxic and possess good thermal stability.Polyethylene glycol monomethyl ether-maleic rosin acid polyester chains aggregated into micelles and the size of micelles gradually increased during the process of heating the solution,and the size gradually decreased after the turning temperature.The aggregation and compaction morphology transition was reversible.In conclusion,the formation of polyethylene glycol monomethyl ether-maleic acid polyester micelles offers some new ideas for the design and development of thermo-sensitive carriers and green surfactants.

关 键 词：温度响应 生物相容性 可逆 形态转变 聚乙二醇单甲醚马来松香酸聚酯 

分 类 号：O636.9[理学—高分子化学]