莫西沙星联合抗痨丸治疗肺结核患者促使痰菌转阴的积极作用  

The positive effect of moxifloxacin combined with antituberculosis pills in the treatment of pulmonary tuberculosis patients to promote the negative effect of sputum bacteria

作　　者：钱洁 李云光 QIAN Jie;LI Yunguang(Department of Infection,Chibi People's Hospital,Chibi,Hubei,437300,China)

机构地区：[1]赤壁市人民医院感染科,湖北赤壁437300

出　　处：《当代医学》2021年第31期61-63,共3页Contemporary Medicine

摘　　要：目的分析莫西沙星联合抗痨丸治疗肺结核患者促使痰菌转阴的积极作用。方法选取2018年1月至2020年6月于本院开展2HRZE/4HR治疗的肺结核患者84例作为研究对象,根据奇偶数法分为对照组(莫西沙星治疗,n=42)与研究组(莫西沙星联合抗痨丸治疗,n=42)。治疗后随访6个月,比较两组血清指标与痰菌转阴率。结果研究组血清C-反应蛋白(CRP)、白介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)与降钙素原(PCT)水平均明显低于对照组(P<0.05)。研究组痰菌转阴率明显高于对照组(P<0.05)。结论莫西沙星联合抗痨丸治疗肺结核的效果显著,可有效改善炎症反应,促进痰菌转阴,值得临床进一步推广运用。Objective To analyze the positive effect of moxifloxacin combined with anti-tuberculosis pills in the treatment of pulmonary tuberculosis patients in promoting the negative effect of sputum bacteria.Methods 84 pulmonary tuberculosis patients who came to our hospital for 2HRZE/4HR treatment were selected as study subjects from January 2018 to June 2020,they were divided into control group(moxifloxacin treatment,n=42)with the study group(moxifloxacin combined with anti-tuberculosis pills,n=42)according to the odd and even number method.Follow-up for 6 months after treatment,compare the two groups'serum indexes and sputum conversion rate.Results The serum C-reactive protein(CRP),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)and procalcitonin(PCT)of the study group were significantly lower than those of the control group(P<0.05).The negative rate of sputum bacteria in the study group was significantly higher than that in the control group(P<0.05).Conclusion Moxifloxacin combined with anti-tuberculosis pills is effective for pulmonary tuberculosis.It can effectively improve the inflammatory response and promote the conversion of sputum bacteria.It can be further promoted in clinical practice.

关 键 词：肺结核 莫西沙星 抗痨丸 痰菌转阴率 

分 类 号：R521[医药卫生—内科学]