改良腹腔镜子宫体楔形切除术联合GnRH-a治疗子宫腺肌病的临床效果  

Clinical Effect of Modified Laparoscopic Wedge Resection of Uterus Combined with GnRH-a in the Treatment of Adenomyosis

作　　者：刘清 LIU Qing(Department of Obstetrics and Gynecology,Xinyang Central Hospital,Xinyang 465200,China)

机构地区：[1]信阳市中心医院妇产科,河南信阳464000

出　　处：《河南医学研究》2021年第31期5821-5824,共4页Henan Medical Research

摘　　要：目的探讨改良腹腔镜子宫体楔形切除术联合促性腺激素释放激素激动剂(GnRH-a)治疗子宫腺肌病(AM)的临床价值。方法选择2020年1月至2021年1月信阳市中心医院收治的80例AM患者作为研究对象,根据随机数表法分为两组,各40例。对照组接受改良腹腔镜子宫体楔形切除术治疗,观察组接受改良腹腔镜子宫体楔形切除术联合GnRH-a治疗。比较两组经量、子宫体积、血清指标、疼痛程度、并发症发生情况。结果术后3个月,观察组经量、子宫体积小于对照组(P<0.05),血清前列腺素F2α(PGF2α)、糖类抗原125(CA125)水平低于对照组(P<0.05),前列腺素E_(2)(PGE_(2))、β-内啡肽水平高于对照组(P<0.05)。术后3、6个月观察组视觉模拟评分(VAS)低于对照组(P<0.05)。两组住院期间并发症发生率相比,差异无统计学意义(P>0.05)。结论改良腹腔镜子宫体楔形切除术联合GnRH-a能够有效减轻AM患者临床症状,缓解痛经,缩小子宫体积,抑制子宫内膜的侵袭。Objective To explore the clinical value of modified laparoscopic wedge resection of the uterus combined with gonadotropin releasing hormone agonist(GnRH-a)in the treatment of adenomyosis(AM).Methods A total of 80 AM patients admitted to Xinyang Central Hospital from January 2020 to January 2021 were selected as the research objects,and were divided into two groups according to the random number table method,with 40 cases in each group.The control group received modified laparoscopic wedge resection of the uterus,and the observation group received modified laparoscopic wedge resection of the uterus combined with GnRH-a treatment.The menstrual volume,uterine volume,serum index,pain degree,and complications were compared between the two groups.Results After 3 months,in the observation group,menstrual volume and uterine volume were smaller than those in the control group(P<0.05),the serum prostaglandin F2α(PGF2α)and carbohydrate antigen 125(CA125)levels were lower than those in the control group(P<0.05),and the levels of prostaglandin E_(2)(PGE_(2))and β-endorphin were higher than those in the control group(P<0.05).Three and six months after surgery,the visual analogue score(VAS)of the observation group was lower than that of the control group(P<0.05).There was no statistical difference in the incidence of complications between the two groups during hospitalization(P>0.05).Conclusion The modified laparoscopic wedge resection of the uterus combined with GnRH-a could effectively alleviate the clinical symptoms of AM patients,relieve dysmenorrhea,reduce the size of the uterus,and inhibit the invasion of the endometrium.

关 键 词：子宫腺肌病 腹腔镜 子宫体楔形切除术 促性腺激素释放激素激动剂 

分 类 号：R713[医药卫生—妇产科学]