复发性自然流产患者血清抗心磷脂抗体、抗β_(2)糖蛋白1抗体的表达及临床意义  

Expression and clinical significance of anticardiolipin antibody and anti β_(2)-glycoprotein-1 antibody in patients with recurrent spontaneous abortion

作　　者：李丽 王彬[2] LI Li;WANG Bin(Department of Rheumatology,Dongguan People's Hospital,Dongguan 523000;Department of Reproductive Medicine,Dongguan People's Hospital,Dongguan 523000)

机构地区：[1]东莞市人民医院风湿科,广东东莞523000 [2]东莞市人民医院生殖医学科,广东东莞523000

出　　处：《当代医药论丛》2021年第21期148-149,共2页

基　　金：2020年东莞市社会科技发展(一般)项目;项目编号:202050715001528。

摘　　要：目的:探讨复发性自然流产患者血清抗心磷脂抗体、抗β_(2)糖蛋白1抗体的表达情况及临床意义。方法:选择208例复发性自然流产患者与86例健康孕妇作为研究对象。将86例健康孕妇设为对照组,将208例复发性自然流产患者中孕周<8周流产的患者设为早期流产组,将其中孕周≥8周流产的患者设为晚期流产组。对三组研究对象血清抗心磷脂抗体、抗β_(2)糖蛋白1抗体的水平进行检测,并对其检测结果进行比较分析。结果:两组流产组患者血清抗心磷脂抗体免疫球蛋白G(IgG)、免疫球蛋白M(IgM)的阳性率和抗β_(2)糖蛋白1抗体IgG、IgM的阳性率均高于对照组孕妇,P<0.05。两组流产组患者血清抗心磷脂抗体IgG、IgM的阳性率及抗β_(2)糖蛋白1抗体IgG、IgM的阳性率相比,P>0.05。结论:复发性自然流产患者血清抗心磷脂抗体、抗β_(2)糖蛋白1抗体的阳性表达率会显著升高,通过对这两项指标进行检测有助于预测孕妇是否会发生自然流产。Objective:To investigate the expression and clinical significance of anticardiolipin antibody and anti-β_(2)-glycoprotein-1 antibody in patients with recurrent spontaneous abortion.Methods:208 patients with recurrent spontaneous abortion and 86 healthy pregnant women were selected as subjects.A total of 86 healthy pregnant women were selected as the control group,208 recurrent spontaneous abortion patients with pregnancy<8 weeks were selected as the early abortion group,and those with pregnancy≥8 weeks were selected as the late abortion group.The levels of anticardiolipin antibody and anti-β_(2)-glycoprotein-1 antibody in serum of the three groups were detected,and the results were compared and analyzed.Results:The positive rates of anticardiolipin antibody immunoglobulin G(IgG)and immunoglobulin M(IgM)and anti-β_(2)glycoprotein 1 antibody IgG and IgM in abortion group were higher than those in control group,P<0.05.The positive rates of anti-cardiolipin antibody IgG and IgM and anti-β_(2)glycoprotein 1 antibody IgG and IgM were compared between the two abortion groups,P>0.05.Conclusion:The positive expression rate of anticardiolipin antibody and anti-β_(2)-glycoprotein-1 antibody in serum of patients with recurrent spontaneous abortion will be significantly increased.The detection of these two indicators is helpful to predict whether spontaneous abortion will occur in pregnant women.

关 键 词：复发性自然流产 抗心磷脂抗体 抗Β2糖蛋白1抗体 

分 类 号：R446[医药卫生—诊断学]