药品、 环境和食品中马兜铃酸分析检测方法的研究进展  

Advances in Detection Methods for Aristolochic Acids in Medicine,Environment and Food

作　　者：张朝辉[1,2] 周娜姣[1] 刘星 陈应庄[1] 郭宾[1] 马铭[1] 陈波[1] ZHANG Zhao-Hui;ZHOU Na-Jiao;LIU Xing;CHEN Ying-Zhuang;GUO Bin;MA Ming;CHEN Bo(Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education of China)and Key Laboratory of Phytochemical R&D of Hunan Province,Hunan Normal University,Changsha 410081,China;Hunan Biological and Electromechanical Polytechnic,Changsha 410127,China)

机构地区：[1]湖南师范大学,化学生物学及中药分析教育部重点实验室,植化单体开发与利用湖南省重点实验室,长沙410081 [2]湖南生物机电职业技术学院,长沙410127

出　　处：《分析化学》2021年第11期1792-1803,共12页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(Nos.21775041,21775040)资助。

摘　　要：马兜铃酸(Aristolochic acids,AAs)是广泛存在于马兜铃科植物中的一类硝基菲类化合物,因其具有不可逆转的肾脏毒性,被国际癌症研究机构列为I级致癌物。马兜铃酸的分析检测方法对马兜铃酸肾病、巴尔干地方性肾病和慢性肾病致病机理的探索和防治等具有重要意义。本文对目前马兜铃酸的常用检测方法进行了概述和比较,重点阐述了高效液相色谱法(HPLC)、液相色谱-质谱联用法(LC-MS)在马兜铃酸分析检测中的相关应用及其最新研究进展,探讨了马兜铃酸检测中存在的问题和面临的挑战,并对其未来发展方向进行了展望。Aristolochic acids(AAs)are a kind of nitrophenanthrene compound in Aristolochiaceae plants.AAs are classified as the Class I carcinogen by the International Agency for Research on Cancer because of their irreversible nephrotoxicity.The analysis of AAs is of great significance for exploring the pathogenic mechanism and preventing from AAs nephropathy(AAN),Balkan endemic nephropathy(BEN)and chronic kidney disease(CKD).The present article summarizes and compares the common methods for detection of AAs,specifically focusing on the applications and the latest advances of high performance liquid chromatography(HPLC)and liquid chromatography-mass spectrometry(LC-MS).The existential problems,the challenges,and the further development of the detection of AAs are fully discussed.

关 键 词：马兜铃酸 肾脏毒性 高效液相色谱法 液相色谱-质谱联用法 检测方法 评述 

分 类 号：O657[理学—分析化学] TQ460.72[理学—化学] TS207.3[医药卫生—药物分析学]