连续性血液净化疗法对多器官功能障碍综合征的治疗效果分析  

Analysis of the effect of continuous blood purification therapy on multiple organ dysfunction syndrome

作　　者：朱颜 ZHU Yan(Dalian Third People’s Hospital,Dalian 116011,China)

机构地区：[1]辽宁省大连市第三人民医院,116011

出　　处：《中国实用医药》2021年第30期19-21,共3页China Practical Medicine

摘　　要：目的探究连续性血液净化(CBP)治疗多器官功能障碍综合征(MODS)的效果。方法58例MODS患者,依据随机数字表法分为对照组与观察组,各29例。对照组予以对症支持治疗,观察组在对症支持治疗基础上予以CBP治疗。对比两组治疗前后生命体征指标、炎性因子水平、生化指标。结果治疗后,观察组体温(36.68±0.33)℃、心率(96.25±4.80)次/min、呼吸频率(25.47±1.98)次/min均低于对照组的(37.60±0.48)℃、(108.73±5.29)次/min、(30.55±2.03)次/min,平均动脉压(94.42±5.73)mm Hg(1 mm Hg=0.133 kPa)高于对照组的(83.87±4.09)mm Hg,差异均具有统计学意义(P<0.05)。治疗后,观察组肿瘤坏死因子-α(TNF-α)为(38.64±5.25)μg/L、白细胞介素-8(IL-8)为(32.58±3.45)μg/L、白细胞介素-6(IL-6)为(44.37±6.21)μg/L、白细胞介素-1β(IL-1β)为(8.95±2.47)μg/L,均低于对照组的(52.12±6.03)、(41.73±4.21)、(60.19±6.88)、(16.28±3.69)μg/L,差异均具有统计学意义(P<0.05)。治疗后,观察组血肌酐(Scr)为(152.41±20.86)μmol/L、血尿素氮(BUN)为(18.54±3.71)mmol/L、总胆红素(TBIL)为(70.59±20.13)μmol/L、丙氨酸转氨酶(ALT)为(80.67±23.73)U/L,均低于对照组的(285.29±22.15)μmol/L、(26.69±3.94)mmol/L、(130.09±24.94)μmol/L、(196.15±46.21)U/L,差异均具有统计学意义(P<0.05)。结论予以MODS患者CBP治疗效果理想,可降低患者机体炎性反应,改善其临床症状体征。Objective To investigate the effect of continuous blood purification(CBP)therapy on multiple organ dysfunction syndrome(MODS).Methods A total of 58 MODS patients were divided into control group and observation group according to random numerical table,with 29 cases in each group.The control group received symptomatic and supportive treatment,and the observation group received CBP therapy on the basis of symptomatic and supportive treatment.The vital signs,inflammatory factor levels,and biochemical indicators before and after treatment were compared between the two groups.Results After treatment,the body temperature(36.68±0.33)℃,heart rate(96.25±4.80)beats/min,and respiratory rate(25.47±1.98)breaths/min of the observation group were lower than(37.60±0.48)℃,(108.73±5.29)beats/min,(30.55±2.03)breaths/min of the control group,and the mean arterial pressure(94.42±5.73)mm Hg(1 mm Hg=0.133 kPa)was higher than(83.87±4.09)mm Hg of the control group.All the differences were statistically significant(P<0.05).After treatment,the tumor necrosis factor-α(TNF-α)(38.64±5.25)μg/L,interleukin-8(IL-8)(32.58±3.45)μg/L,interleukin-6(IL-6)(44.37±6.21)μg/L,interleukin-1β(IL-1β)(8.95±2.47)μg/L of the observation group were lower than(52.12±6.03),(41.73±4.21),(60.19±6.88),(16.28±3.69)μg/L of the control group,and the difference was statistically significant(P<0.05).After treatment,the serum creatinine(Scr)(152.41±20.86)μmol/L,blood urea nitrogen(BUN)(18.54±3.71)mmol/L,total bilirubin(TBIL)(70.59±20.13)μmol/L,alanine aminotransferase(ALT)(80.67±23.73)U/L of the observation group were lower than(285.29±22.15)μmol/L,(26.69±3.94)mmol/L,(130.09±24.94)μmol/L,(196.15±46.21)U/L of the control group,and the difference was statistically significant(P<0.05).Conclusion CBP therap has ideal effect on patients with MODS,and it can reduce the patient’s body inflammatory response and improve their clinical symptoms and signs.

关 键 词：多器官功能障碍综合征 炎性因子 连续性血液净化 常规血液净化 生命体征 

分 类 号：R459.7[医药卫生—急诊医学]