机械碎栓联合导管内药物溶栓治疗外周动脉阻塞性疾病的效果分析  

Analysis of the effect of mechanical fragmentation and catheter-directed thrombosis in the treatment of peripheral arterial obstructive disease

作　　者：罗磊 LUO Lei(Interventional Department,Tai’an Traditional Chinese Medicine Hospital,Tai’an 271000,China)

机构地区：[1]泰安市中医医院介入科,271000

出　　处：《中国实用医药》2021年第30期59-61,共3页China Practical Medicine

摘　　要：目的探讨外周动脉阻塞性疾病患者给予机械碎栓联合导管内药物溶栓治疗的临床效果。方法70例外周动脉阻塞性疾病患者,依据治疗方案分为观察组与对照组,各35例。观察组患者为机械碎栓+导管内药物溶栓,对照组患者为传统动脉内导管药物溶栓。比较两组疗效、临床指标、静息疼痛评分、缺血性溃疡面积。结果观察组治疗总有效率为100.00%,高于对照组的88.57%,差异有统计学意义(P<0.05)。观察组的溶栓时间(7.39±3.05)min短于对照组的(16.59±7.25)min,尿激酶药物用量(35.06±7.59)万U少于对照组的(119.63±39.75)万U,差异均有统计学意义(P<0.05)。治疗后,观察组静息疼痛评分低于对照组,缺血性溃疡面积小于对照组,差异有统计学意义(P<0.05)。结论外周动脉阻塞性疾病患者应用机械碎栓+导管内药物溶栓的介入溶栓疗法效果满意,且治疗时间短、药物用量小,值得临床应用及推广。Objective To discuss the clinical effect of mechanical fragmentation and catheter-directed thrombosis in the treatment of peripheral arterial obstructive disease.Methods A total of 70 patients with peripheral arterial obstructive disease were divided into observation group and control group according to different treatment regimens,with 35 cases in each group.Patients in the observation group were treated with mechanical fragmentation and catheter-directed thrombosis,and patients in the control group were treated with traditional intra-arterial catheter drug thrombolysis.The clinical efficacy,clinical indicators,resting pain score,and area of ischemic ulcer were compared between the two groups.Results The total effective rate of treatment in the observation group was 100.00%,which was higher than 88.57%in the control group,and the difference was statistically significant(P<0.05).The thrombolysis time(7.39±3.05)min of the observation group was shorter than(16.59±7.25)min of the control group,and the dosage of urokinase(35.06±7.59)million U was less than(119.63±39.75)million U of the control group.All the differences were statistically significant(P<0.05).After treatment,the resting pain score of the observation group was lower than that of the control group,and the area of ischemic ulcer was smaller than that of the control group.All the differences were statistically significant(P<0.05).Conclusion Combination of mechanical fragmentation and catheter-directed thrombosis has a satisfactory effect for patients with peripheral arterial obstructive disease,with short treatment time and low drug dosage,which is worthy of clinical application and promotion.

关 键 词：外周动脉阻塞性疾病 机械碎栓 导管内药物溶栓 

分 类 号：R543.5[医药卫生—心血管疾病]