COVID-19患者腹泻发生机制研究进展  

Research progress on the mechanism of diarrhea in patients with COVID-19

作　　者：张少罡 王冬[1] 宋洁 张晓岚[1] ZHANG Shao-gang;WANG Dong;SONG Jie;ZHANG Xiao-lan(Department of Gastroentology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China)

机构地区：[1]河北医科大学第二医院消化内科,河北石家庄050000

出　　处：《基础医学与临床》2021年第11期1684-1687,共4页Basic and Clinical Medicine

摘　　要：新型冠状病毒肺炎(COVID-19)患者主要表现为发热、咳嗽等呼吸系统症状,但需警惕部分患者伴随消化系统症状,如腹泻、恶心、呕吐等,甚至少数患者以腹泻等不典型症状为首发表现。新型冠状病毒2(SARS-CoV-2)感染肠上皮细胞、肠道菌群失调、治疗药物、精神心理因素、细胞因子风暴及原发基础疾病加重等可导致COVID-19患者出现腹泻,临床医师应提高对COVID-19患者表现为消化系统症状的警惕性,并对有腹泻表现的COVID-19患者进行及时有效的治疗。Patients with corona virus disease 2019(COVID-19)mainly have fever,cough and other respiratory symptoms,but it is necessary to be aware that some patients are complicated by digestive symptoms,such as diarrhea,nausea and vomiting,and even a few patients show atypical symptoms such as diarrhea as the first presentation.This article reviews the mechanism of SARS-CoV-2 infection with digestive tract symptoms,change of intestinal microbiota,therapeutic drugs,psychosocial factors,cytokine storm and aggravation of primary underlying diseases,etc.,so as to sharpen clinicians vigilance against COVID-19 patients with digestive system symptoms,and provide theoretical basis for corresponding treatment.

关 键 词：COVID-19 腹泻 机制 

分 类 号：R512.99[医药卫生—内科学]