钙离子稳态的调控在糖尿病相关心房颤动中的作用  

Regulation of Calcium Homeostasis in Diabetes-Related Atrial Fibrillation

作　　者：高婧晗 刘飞 杨晓蕾[1] 夏云龙[1] GAO Jinghan;LIU Fei;YANG Xiaolei;XIA Yunlong(The First Affiliated Hospital of Dalian Medical University,Dalian 116011,Liaoning,China)

机构地区：[1]大连医科大学附属第一医院,辽宁大连116011

出　　处：《心血管病学进展》2021年第10期888-891,共4页Advances in Cardiovascular Diseases

摘　　要：糖尿病作为最常见的慢性疾病,是心房颤动最重要的危险因素之一。众多研究表明心房电重构在糖尿病相关心房颤动的发生机制中起重要作用,而钙超载是引起心房电重构发生的重要原因之一。心肌细胞主要通过调节钙调蛋白信号通路和L型钙通道来调控细胞内的钙离子浓度从而维持钙稳态,同时特异性miRNA的表达改变与钙稳态失衡密切相关。现从钙离子稳态失衡的角度探讨糖尿病诱发心房颤动的机制进展。Diabetes mellitus,as the most common chronic disease,is one of the most important risk factors for atrial fibrillation.Numerous studies have shown that atrial electrical remodeling plays an important role in the pathogenesis of diabetes-related atrial fibrillation.Calcium overload is one of the most important causes of atrial electrical remodeling.Cardiomyocytes mainly regulate the intracellular calcium ion concentration by regulating calmodulin signaling pathway and L-type calcium channel to maintain calcium homeostasis.In the meanwhile,the specific expression changes of miRNA are closely related to the calcium homeostasis.This review will discuss the progress of the mechanism of diabetes-related atrial fibrillation from the perspective of calcium homeostasis.

关 键 词：心房颤动 糖尿病 钙离子 

分 类 号：R587.2[医药卫生—内分泌] R541.75[医药卫生—内科学]