生物催化轴手性化合物的不对称合成进展  

Progress in biocatalytic asymmetric synthesis of axially chiral compounds

作　　者：尚亚莉 袁波 费强 SHANG Ya-li;YUAN Bo;FEI Qiang(School of Chemical Engineering and Technology,Xi’an Jiaotong University,Xi’an 710049,China)

机构地区：[1]西安交通大学化学工程与技术学院,陕西西安710049

出　　处：《高校化学工程学报》2021年第5期775-788,共14页Journal of Chemical Engineering of Chinese Universities

基　　金：国家自然科学基金(32171462);国家自然科学基金青年基金(21706205);国家博士后项目(2018M633518);陕西省自然科学基金(2018JQ2062)。

摘　　要：轴手性化合物是许多天然产物、药物中间体、手性配体的核心骨架,在手性化合物中占有重要地位。与金属催化剂催化的不对称化学偶联反应等化学方法相比,生物催化方法具有选择性高、反应条件温和、环保等优势。随着酶的改造等关键技术的快速发展,酶催化轴手性化合物的合成成为新的研究热点与难点。从动力学拆分(kinetic resolution,KR)、动态动力学拆分(dynamic kinetic resolution,DKR)以及去对称化(desymmetrization)等不对称合成方法入手,综述了生物催化轴手性化合物的合成领域的主要研究成就,并阐述了此方向的发展前景、应用及存在的问题。Axially chiral compounds are valuable chiral compounds used as core skeleton of natural products,pharmaceutical intermediates and chiral ligands. Compared to asymmetric couplings catalyzed by metal catalysts or other asymmetric chemical methods, biocatalytic methods are mild, environmental friendly and highly selective. With the fast development of enzyme engineering and directed evolution, biocatalytic asymmetric synthesis of axially chiral compounds has attracted increasing research interest. This article reviews major progress in the area of biocatalytic synthesis of axially chiral compounds starting from different synthetic methods kinetic resolution(KR), dynamic kinetic resolution(DKR) and desymmetrization, and discusses the prospects of applications and existing problems of this area.

关 键 词：生物催化 轴手性化合物 不对称合成 动力学拆分 动态动力学拆分 去对称化 

分 类 号：TQ55[化学工程]