2018年东营市疑似预防接种异常反应监测分析  

Analysis on surveillance of adverse events following immunization in Dongying,2018

作　　者：徐爱民[1] 马有祥[2] 王莉莉[3] 张英杰 刘新民 XU Ai-min;MA You-xiang;WANG Li-li;ZHANG Ying-jie;LIU Xin-min(Department of Tuberculosis Control,Dongying Center for Disease Control and Prevention,Shandong257091,China)

机构地区：[1]东营市疾病预防控制中心结核病防治科,山东257091 [2]东营市疾病预防控制中心传染病防治科 [3]东营市疾病预防控制中心慢病防治科 [4]山东省疾病预防控制中心免疫规划所 [5]东营市疾病预防控制中心免疫规划科

出　　处：《医学动物防制》2021年第10期991-995,共5页Journal of Medical Pest Control

基　　金：山东省医药卫生科技发展计划项目(2014WS0115)。

摘　　要：目的分析2018年东营市疑似预防接种异常反应(adverse events following immunization, AEFI)发生特征,评价AEFI监测系统的运转情况。方法通过全国AEFI监测信息管理系统收集2018年东营市AEFI个案数据,采用描述性方法对相关指标进行流行病学分析。结果 2018年东营市AEFI监测指标均达到监测方案要求;共报告AEFI病例259例,比2017年同期报告(373例)下降30.56%;2018年已审核的259例AEFI病例中,一般反应251例,占96.91%;异常反应5例,占1.93%;偶合症3例,占1.16%。AEFI发生率为29.62/10万剂,异常反应发生率为5.11/100万剂。3岁以下报告最多(246例),占94.98%;接种0~1 d发生227例,占87.64%;发生AEFI前3位的疫苗依次为:百白破疫苗(无细胞)、乙脑疫苗(减毒)、A群流脑疫苗;报告的AEFI中,位于前3位的临床诊断依次为:发热/红肿/硬结、过敏反应-麻疹猩红热样皮疹、卡介苗淋巴结炎;异常反应病例申报省级补偿10例,市级补偿3例,省级补偿到位7例,到位补偿资金160.010 5万元。结论 2018年东营市AEFI监测敏感性和监测质量尚需提高;AEFI常发生在小年龄儿童、免疫规划疫苗、首剂接种、接种后1~2 d,此为监测重点;积极推行将严重异常反应纳入医保大病补偿,缓解AEFI病例家庭经济负担。Objective To analysis the occurrence characteristics of suspected adverse events following immunization(AEFI) in Dongying in 2018,and to evaluate the operations of AEFI surveillance system.Methods Individual AEFI data were collected through national AEFI information system in Dongying in 2018.The descriptive methodology was used to conduct epidemiological analysis on related indices.Results All of the AEFI monitoring indices in Dongying in 2018 meet the requirements of the surveillance program.A total of 259 AFET cases were reported, being 30.56% lower than that reported in the same period last year(373).In reviewed 259 AEFI cases, there were 251 patients with general events, accounting for 96.91%,5 patients with adverse events, accounting for 1.93%,and 3 patients with coincidences, accounting for 1.16%.The AEFI showed the incidence rate in 29.62/100 000 doses, incidence of adverse events in 5.11/1 000 000 doses.The AEFI cases mainly occurred in the small children less than 3 years old(246 cases),accounting for 94.98%.87.64%,227 patients were reported to suffer from adverse events within 0-1 days following immunization.The top three vaccines with maximum reported AEFI cases were DPT vaccine(acellular),jevaccine(attenuated),meningococcal serogroup A vaccine.The top three clinical diagnosis findings were swelling/fever/sclerosis, allergic reaction-measles scarlet fever like rash, lymphadenitis of Bacilli Calmette-Guerin vaccine(BCG).10 patients with adverse events were reported for provincial benefits, 3 patients were reported for municipal benefits, the provincial benefits for 7 patientsamounted in RMB 1 600 105 has been available.Conclusion The sensitivity and quality of AEFI surveillance in Dongying remains to be improved.AEFIs frequently occurs during key surveillance periods involving younger children, immunization program vaccine and first dose and within 1 day after immunization.The inclusion of severe abnormal reactions in medical insurance benefits for serious diseases should be actively promoted to ease e

关 键 词：疫苗 疑似预防接种异常反应 监测 分析 接种情况 

分 类 号：R186[医药卫生—流行病学]