自身免疫性甲状腺疾病患者甲状腺体积与自身抗体关系研究  

Relationship between thyroid volume and autoantibodies in patients with autoimmune thyroid disease

作　　者：郭俊敏[1] 王青平[2] 桑志萍[2] 张峰峰[3] 贾清珍[4] Guo Junmin;Wang Qingping;Sang Zhiping;Zhang Fengfeng;Jia Qingzhen(Department of Ultrasound,Shanxi Institute for Endemic Disease Prevention and Treatment,Linfen 041000,China;Internal Medicine,Shanxi Institute for Endemic Disease Prevention and Treatment,Linfen 041000,China;Clinical Laboratory,Shanxi Institute for Endemic Disease Prevention and Treatment,Linfen 041000,China;Department of Iodine Deficiency Disorders,Shanxi Institute for Endemic Disease Prevention and Treatment,Linfen 041000,China)

机构地区：[1]山西省地方病防治研究所超声室,临汾041000 [2]山西省地方病防治研究所内科,临汾041000 [3]山西省地方病防治研究所检验科,临汾041000 [4]山西省地方病防治研究所碘缺乏病研究室,临汾041000

出　　处：《中华地方病学杂志》2021年第10期845-848,共4页Chinese Journal of Endemiology

基　　金：山西省卫生健康委科研课题(2018008)。

摘　　要：目的观察自身免疫性甲状腺疾病(AITD)患者甲状腺体积与自身抗体的关系,探讨影响AITD患者甲状腺肿大的因素。方法选择2019年11月至2020年10月于山西省地方病防治研究所附属医院初诊的AITD成人患者,进行问卷调查,体格检查,甲状腺功能、甲状腺自身抗体以及血清碘含量测定和甲状腺超声检查,分析甲状腺体积与甲状腺自身抗体的相关性。结果共纳入147例初诊成人AITD患者,其中Graves病(GD)患者63例,男性30例、女性33例;慢性淋巴细胞性甲状腺炎(HT)患者84例,男性29例、女性55例。男、女性GD患者的甲状腺体积与促甲状腺素受体抗体(TRAb)水平均呈正相关[相关系数(r)_(男性)=0.515,r_(女性)=0.412,P均<0.05]。男、女性HT患者的甲状腺体积与甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TGAb)水平均不相关(r_(男性)=-0.137、0.168,r_(女性)=0.184、-0.088,P均>0.05)。男、女性HT患者的TPOAb水平与TGAb水平之间均不相关(r_(男性)=0.153,r_(女性)=0.102,P均>0.05)。男、女性GD患者和HT患者的甲状腺体积与血清碘水平均不相关(r_(男性)=0.230、0.013,r_(女性)=0.096、0.069,P均>0.05)。结论GD患者的TRAb水平与甲状腺体积呈正相关。Objective To study the relationship between thyroid volume(TV)and thyroid autoantibodies in patients with autoimmune thyroid disease(AITD),and to explore the factors affecting goiter in patients with AITD.Methods The newly diagnosed AITD adult patients in the Affiliated Hospital of Shanxi Institute for Endemic Disease Prevention and Control from November 2019 to October 2020 were selected for questionnaire survey,physical examination,thyroid function and thyroid autoantibody test,determination of serum iodine content and thyroid ultrasound,and the correlation between thyroid volume and thyroid autoantibody was analyzed.Results A total of 147 newly diagnosed adult AITD patients were included,including 63 cases of Graves'disease(GD,30 males and 33 females)and 84 cases of chronic lymphocytic thyroiditis(HT,29 males and 55 females).The TV of male and female patients with GD was positively correlated with the levels of thyrotropin receptor antibody(TRAb)(r_(men)=0.515,r_(women)=0.412,P<0.05).The TV of male and female patients with HT was not correlated with the levels of thyroid peroxidase antibody(TPOAb)and thyroglobulin antibody(TGAb,r_(men)=-0.137,0.168,r_(women)=0.184,-0.088,P>0.05).There were no correlation between TPOAb levels and TGAb levels in male and female HT patients(r_(men)=0.153,r_(women)=0.102,P>0.05).The TV of male and female patients with GD or HT was not correlated with the serum levels of iodine(r_(men)=0.230,0.013,r_(women)=0.096,0.069,P>0.05).Conclusion TRAb level is positively correlated with the TV in GD patients.

关 键 词：自身免疫性甲状腺疾病 甲状腺自身抗体 甲状腺肿 

分 类 号：R581[医药卫生—内分泌]