血清HE4、CA125、CA153检测对子宫内膜癌的诊断价值及与病情进展的关系  

Diagnostic value of serum HE4,CA125,CA153 detection on endometrial cancer and its correlation with disease progression

作　　者：梁紫影 曹丽娟[1] 张秀艳[1] 纪利娜[1] LIANG Ziying;CAO Lijuan;ZHANG Xiuyan;JI Lina(Department of Gynecology,Chengde Municipal Central Hospital,Chengde,Hebei 067000,China)

机构地区：[1]河北省承德市中心医院妇科,河北承德067000

出　　处：《国际检验医学杂志》2021年第21期2611-2613,2618,共4页International Journal of Laboratory Medicine

基　　金：河北省医学科学研究课题计划项目(20200349)。

摘　　要：目的研究血清人附睾分泌蛋白4(HE4)、糖类抗原125(CA125)、糖类抗原153(CA153)检测对子宫内膜癌的诊断价值及与病情进展的关系。方法选取2019年3月至2020年4月该院收治的子宫内膜癌患者96例作为子宫内膜癌组,同时选取在该院进行健康体检的96例女性志愿者作为对照组。检测所有研究对象血清中HE4、CA125、CA153水平。结果子宫内膜癌组血清HE4、CA125、CA153水平均高于对照组(P<0.05)。子宫内膜癌组患者中,有淋巴结转移的患者血清HE4、CA125、CA153水平均高于无淋巴结转移的患者(P<0.05),分化程度为低分化的患者血清HE4、CA125、CA153水平高于分化程度为中分化和高分化的患者(P<0.05),肌层浸润深度≥1/2肌层的患者血清HE4、CA125、CA153水平高于肌层浸润深度<1/2肌层和无肌层浸润的患者(P<0.05)。HE4、CA125、CA153三项联合检测诊断子宫内膜癌的灵敏度、特异度、准确率均高于单项检测(P<0.05)。结论血清HE4、CA125、CA153在子宫内膜癌患者中呈现高表达,与肿瘤有无淋巴结转移、分化程度和肌层浸润深度关系密切,诊断价值大。Objective To investigate the diagnostic value of the detection of serum human epididymal secreted protein 4(HE4),glucose antigen 125(CA125)and glucose antigen 153(CA153)in endometrial cancer and its correlation with disease progression.Methods Ninety-six patients with endometrial cancer treated in this hospital from March 2019 to April 2020 were selected as the endometrial cancer group,and contemporaneous 96 female volunteers undergoing the physical examination in this hospital were selected as the control group.Serum HE4,CA125,CA153 levels were tested in all study subjects.Results Serum HE4,CA125,CA153 levels in the endometrial cancer group were higher than those in the control group(P<0.05).In the endometrial cancer group,the serum HE4,CA125,CA153 expression levels in the patients with lymph node metastasis were higher than those in the patients without lymph node metastasis(P<0.05),the serum HE4,CA125,CA153 expression levels in the patients with low differentiation degree were higher than those in the patients with moderate and high differentiation degree(P<0.05),and the serum HE4,CA125,CA153 expression levels in the patients with muscular layer infiltration depth≥1/2 muscular layer were higher than those in the patients with muscular layer infiltration depth<1/2 muscular layer,and the differences were statistically significant(P<0.05).The sensitivity,specificity and accuracy of combined detection of HE4,CA125 and CA153 in diagnosing endometrial cancer were higher than those of single item detection(P<0.05).Conclusion HE4,CA125 and CA153 were highly expressed in endometrial carcinoma,which is closely related to the lymph node metastasis,differentiation degree and muscular layer infiltration depth,and their diagnostic value is significant.

关 键 词：人附睾分泌蛋白4 糖类抗原125 糖类抗原153 子宫内膜癌 

分 类 号：R446.1[医药卫生—诊断学]