血清vWF:Ag、Claudin-5及sTM联合检测在ARDS患儿早期诊断及预后评估中的应用  

Application of serum vWF:Ag,Claudin-5 and sTM combined detection in early diagnosis and prognostic evaluation of children patients with ARDS

作　　者：何琛璐 王雪君 刘润武 许钦 HE Chenlu;WANG Xuejun;LIU Runwu;XU Qin(Department of Emergency,Qinghai Provincial Women and Children′s Hospital,Xining,Qinghai 810000,China;Department of Quality Control,Qinghai Provincial Women and Children′s Hospital,Xining,Qinghai 810000,China;Infection Clinic,Qinghai Provincial Women and Children′s Hospital,Xining,Qinghai 810000,China)

机构地区：[1]青海省妇女儿童医院急诊科,青海西宁810000 [2]青海省妇女儿童医院质控科,青海西宁810000 [3]青海省妇女儿童医院感染门诊,青海西宁810000

出　　处：《国际检验医学杂志》2021年第21期2614-2618,共5页International Journal of Laboratory Medicine

基　　金：青海省科技计划项目(2019-ZJ-T06)。

摘　　要：目的研究血清血管性血友病因子抗原(vWF:Ag)、Claudin-5及可溶性血栓调节蛋白(sTM)在急性呼吸窘迫综合征(ARDS)患儿早期诊断及预后评估中的价值。方法将该院2016年1月至2020年1月收治的56例ARDS患儿纳为ARDS组,40例ARDS风险患儿纳为风险组,同时将30例健康志愿儿童纳为对照组。并根据柏林定义下的氧合指数,将ARDS患儿分为中轻度组与重度组。随访28 d,统计ARDS患儿生存情况,并将其分为存活组与死亡组。分别比较ARDS组、风险组、对照组以及不同病情、不同预后ARDS患儿血清vWF:Ag、Claudin-5及sTM水平,分析血清vWF:Ag、Claudin-5及sTM在诊断ARDS及预测患儿预后中的价值。结果血清vWF:Ag、Claudin-5及sTM水平在ARDS组、风险组及对照组依次下降(P<0.05),且任意两组间血清vWF:Ag、Claudin-5及sTM水平差异均有统计学意义(P<0.05);重度组ARDS患儿血清vWF:Ag、Claudin-5及sTM水平均明显高于中轻度组(P<0.05);ARDS死亡组患儿血清vWF:Ag、Claudin-5及sTM水平明显高于存活组(P<0.05);绘制ROC曲线发现,血清vWF:Ag、Claudin-5及sTM在诊断ARDS及预测ARDS患儿预后中均具有一定效能。结论ARDS患儿血清vWF:Ag、Claudin-5及sTM水平均异常升高,且vWF:Ag、Claudin-5及sTM在ARDS诊断及预后评估中均具有一定的效能。Objective To investigate the value of serum von Willebrand factor antigen(vWF:Ag),Claudin-5 and soluble thrombomodulin(sTM)in early diagnosis and prognosis evaluation of children patients with acute respiratory distress syndrome(ARDS).Methods Fifty-six children cases of ARDS treated in this hospital from January 2016 to January 2020 were included in the ARDS group,40 children cases of ARDS risk in the risk group and at the same time 30 healthy voluntary children were in the control group.According to the oxygenation index under the Berlin definition,the ARDS children cases were divided into the mild-to-moderate group and severe group.The follow up lasted for 28 d.The survival situation of ARDS children cases was statistically analyzed.The cases were divided into the survival group and death group.Serum vWF:Ag,Claudin-5 and sTM levels were compared among the ARDS group,risk group and control group,and among the ARDS children cases with different disease conditions and different prognosis.Then the value of serum vWF:Ag,Claudin-5 and sTM levels in the diagnosis of ARDS and prediction of the prognosis of the children patients was analyzed.Results Serum vWF:Ag,Claudin-5 and sTM levels showed the in turn downward trend in the ARDS group,risk group and control group,moreover the difference in serum vWF:Ag,Claudin-5 and sTM levels between any two groups showed statistic significnce(P<0.05).The levels of serum vWF:Ag,Claudin-5 and sTM in the severe ARDS group were significantly higher than those in the mild-to-moderate group(P<0.05);the serum vWF:Ag,Claudin-5 and sTM levels in the death group were significantly higher than those in the survival group(P<0.05);the drawn receiver operating characteristic(ROC)curve found that serum vWF:Ag,Claudin-5 and sTM had a certain efficiency in diagnosing ARDS and prediction the prognosis of children patients with ARDS.Conclusion Serum levels of vWF:Ag,Claudin-5 and sTM are abnormally increased in children patients with ARDS,moreover which have a certain efficiency in the diagnosis and

关 键 词：血管性血友病因子抗原 CLAUDIN-5 可溶性血栓调节蛋白 急性呼吸窘迫综合征 早期诊断 预后预测 

分 类 号：R446.11[医药卫生—诊断学]