副猪嗜血杆菌毒力基因及其致病机制研究进展  

Progress on Virulence Genes and Pathogenesis of Haemophilus parasuis

作　　者：叶俊贤 刘郁夫 冯夏宁 陈瑞爱 YE Jun-xian;LIU Yu-fu;FENG Xia-ning;CHEN Rui-ai(Zhaoqing Institute of Biotechnology Co.,Ltd.,Zhaoqing,Guangdong,526238,China;College of Veterinary Medicne,South China Agricultural University,Guangzhou,Guangdong,510642,China;Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology,Zhaoqing,Guangdong,526238,China)

机构地区：[1]华农(肇庆)生物产业技术研究院有限公司,肇庆526238 [2]华南农业大学兽医学院,广州510642 [3]岭南现代农业科学与技术广东省实验室肇庆分中心,肇庆526238

出　　处：《动物医学进展》2021年第11期90-94,共5页Progress In Veterinary Medicine

基　　金：肇庆市西江创新创业团队项目。

摘　　要：副猪嗜血杆菌是养猪场重要的细菌性病原之一。副猪嗜血杆菌的致病机制研究主要集中于毒力基因的功能解析和细菌与宿主之间相互作用方面。近年来随着基因组学数据的不断完善,以及对细菌致病机制科学认识的不断深入,科研人员在副猪嗜血杆菌致病机制研究方面取得不少进展。论文对最近几年新报道的副猪嗜血杆菌膜蛋白、转录调控机制以及副猪嗜血杆菌与宿主之间互作的相关研究做一综述,可为副猪嗜血杆菌新型防控技术和新药研发提供参考。Haemophilus parasuis is one of the most important bacterial pathogens in pig farms.At present,the pathogenic mechanism of Haemophilus parasuis mainly focuses on the functional analysis of virulence genes and the interaction between bacteria and host.In recent years,with the continuous improvement of genomics data and the deepening of scientific understanding of bacterial pathogenesis,researchers have made a lot of progress in the pathogenesis of Haemophilus parasuis.This paper briefly introduces the membrane proteins of Haemophilus parasuis,the transcriptional regulation mechanism and the interaction between Haemophilus parasuis and host,which can provide reference for new technology of prevention and control and new drug development of Haemophilus parasuis.

关 键 词：副猪嗜血杆菌 毒力基因 致病机制 

分 类 号：S855.1[农业科学—临床兽医学]