环形泰勒虫转化细胞中关键分子的研究现状  

Current Status of Key Molecules in Transformed Cells of Theileria annulata

作　　者：蒋晨 李霞 史康妍 赵保才 周子成 赵洪喜[1] JIANG Chen;LI Xia;SHI Kang-yan;ZHAO Bao-cai;ZHOU Zi-chen;ZHAO Hong-xi(Agricultural College,Ningxia University,Yinchuan,Ningxia,750021,China)

机构地区：[1]宁夏大学农学院,宁夏银川750021

出　　处：《动物医学进展》2021年第11期116-120,共5页Progress In Veterinary Medicine

基　　金：宁夏自然科学基金项目(2021A1014)。

摘　　要：环形泰勒虫病是由环形泰勒虫寄生于牛的淋巴细胞和红细胞内所引起的蜱传性血液原虫病,是危害世界养牛业最严重的寄生虫病之一。环形泰勒虫在侵入动物机体时,致病阶段主要发生在转化细胞中,因此,环形泰勒虫转化细胞中各关键分子是研究热点,如子孢子表面抗原蛋白SPAG-1、裂殖体表面蛋白TASP、裂殖子蛋白Tams1和热应激蛋白Hsp70等,这些蛋白不仅具有重要的生理功能,还与宿主蛋白相互发生作用,使宿主致病,但这些蛋白还具有很好的免疫原性,可能在治疗和预防该病方面起到有效作用。Annular theileriasis is a tick-borne blood protozoal disease caused by Theileria annulata parasitized in the lymphocytes and red blood cells of cattle.It is one of the most serious parasitic diseases in cattle industry in the world.When T.annulata invades animals,the pathogenic stage mainly occurs in transformed cells.Therefore,the key molecules in the transformed cells of T.annulata are the research hotspot,such as sporozoite surface antigen protein spag-1,schizosome surface protein tasp,merozoite protein Tams1 and heat stress protein Hsp70.These proteins not only have important physiological functions,but also interact with host proteins.These proteins also have good immunogenicity and may play an effective role in treatment and prevention.

关 键 词：环形泰勒虫 免疫蛋白 关键分子 

分 类 号：S852.729[农业科学—基础兽医学] S858.23[农业科学—兽医学]