消化内分泌与糖脂代谢  

Gut endocrine in glucose and lipid metabolism

作　　者：梁源 孙立君 尹悦 张炜真[1] Liang Yuan;Sun Lijun;Yin Yue;Zhang Weizhen(Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100191,China)

机构地区：[1]北京大学医学部生理学与病理生理学系,100191

出　　处：《国际内分泌代谢杂志》2021年第4期290-294,共5页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(81730020,81930015,82070592);科技部资助课题(2017YFC0908900)。

摘　　要：消化道内分泌细胞及其分泌的多种激素通过外周和中枢等多种作用途径参与调节机体糖脂代谢。研究发现,胃饥饿素(ghrelin)、促胰液素(secretin)、胆囊收缩素(CCK)、胰高血糖素样肽-1(GLP-1)、肠抑胃肽(GIP)和多肽YY(PYY)等胃肠激素控制食物的摄入、消化与吸收,调节胰岛素分泌,并作用于肝脏、脂肪等外周代谢器官调节机体糖脂稳态。肥胖、2型糖尿病等代谢性疾病与胃肠激素分泌异常密切相关。因此,以胃肠激素作为干预靶点的药物备受关注。对消化道内分泌细胞与激素的深入研究将为治疗代谢性疾病提供新方向。Gastrointestinal endocrine cells and relevant hormones function to regulate glucose and lipid metabolism through both peripheral and central pathways.Studies have showed that gastrointestinal hormones including ghrelin,secretin,cholecystokinin(CCK),glucagon-like peptide-1(GLP-1),gastric inhibitory peptide(GIP)and peptideYY(PYY),play pivotal roles in the modulation of food intake,insulin secretion and lipid metabolism in peripheral organs.Metabolic diseases such as obesity and type 2 diabetes are closely related to gastrointestinal hormone abnormalities.Further study of gastrointestinal endocrine cells and hormones will provide a novel strategy for the treatment of metabolic diseases.

关 键 词：胃肠道内分泌细胞 胃肠道激素 糖脂代谢 2型糖尿病 肥胖 

分 类 号：R335[医药卫生—人体生理学]