肠源神经酰胺与代谢性疾病  

Relationship between intestinal ceramide and metabolic diseases

作　　者：王鹏程 姜长涛 Wang Pengcheng;Jiang Changtao(Department of Physiology and Pathophysiology,School of Basic Medical Sciences,Peking University,Key Laboratory of Molecular Cardiovascular Science,Ministry of Education,Beijing 100191,China)

机构地区：[1]北京大学基础医学院生理与病生理学系,教育部心血管国家重点实验室,100191

出　　处：《国际内分泌代谢杂志》2021年第4期295-299,共5页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金(91857115,31925021,81921001);国家重点研发计划(2018YFA0800700)。

摘　　要：神经酰胺作为结构骨架可构成各种复杂鞘脂,是脂毒性发挥作用的核心鞘脂代谢物。近年来多项研究表明,肠源神经酰胺在多种代谢性疾病进程中发挥重要作用,可以通过激活不同组织和细胞的线粒体氧化应激、内质网稳态失调及炎性反应机制等影响疾病进程。肠组织能够直接感知肠道微环境变化(如饮食结构变化、菌群结构及其代谢产物改变等),响应多种不同的信号刺激(如胆汁酸、低氧和炎性反应信号等),激活包括法尼酯衍生物X受体(FXR)、缺氧诱导因子-2α(HIF-2α)等信号调节通路,以直接或间接的方式调控神经酰胺代谢。因此,深入探究肠源神经酰胺对不同代谢性疾病发展过程的影响,将为预防和治疗相关疾病提供重要的理论和实践依据。As the basic skeleton to form various complex sphingolipids,ceramide is the core sphin-golipid metabolite that mediates lipotoxicity.Recent years,researchers have found that intestinal ceramide plays an increasingly important role in the process of metabolic diseases.Ceramide could affect the process of different diseases by regulating mitochondrial oxidative stress,imbalance of endoplasmic reticulum homeostasis or inflammatory response of different tissues or its target cells.Intestinal tissue can directly sense changes in intestinal microenvironment(such as dietary,microbiota and its metabolites changes,etc.),respond to different signal stimuli(such as bile acids,hypoxia and inflammatory signals,etc.),which could activate farnesoid X receptor(FXR),hypoxia-inducible factor(HIF)-2a and other signal pathways regulating ceramide metabolism in a direct or indirect manner.Therefore,it is particularly necessary to explore the influence of intestinal ceramide on the development of different diseases for the prevention and treatment of related diseases.

关 键 词：肠源神经酰胺 代谢性疾病 法尼酯衍生物X受体 缺氧诱导因子-2Α 

分 类 号：R589[医药卫生—内分泌]