运动介导miRNAs调控白色脂肪棕色化的研究进展  

Advances in Research on Exercise-Mediated miRNAs Regulating White Fat Browning

作　　者：刘源[1] Liu Yuan(Shandong Jianzhu University,Jinan 250101,Shandong,China)

机构地区：[1]山东建筑大学,山东济南250101

出　　处：《体育科技文献通报》2021年第11期194-199,共6页Bulletin of Sport Science & Technology

摘　　要：随着对微小RNA (microRNA,miRNA)种类、结构和生物学功能研究的不断深入,其在机体代谢调控、疾病的预防治疗等方面的作用受到了广泛关注。miRNAs作为生物过程的重要调节因子,近年来成为调节脂代谢生物过程的研究热点,尤其在调控白色和棕色脂肪细胞的分化以及棕色化过程中,是研究的新靶点。本文通过综述miRNAs对白色脂肪棕色化的正负向调控作用以及运动对miRNAs、白色脂肪棕色化的影响,探究运动调控miRNAs对白色脂肪棕色化的作用机制及生理学意义,展望白色脂肪棕色化的研究前景,给实验者提供新型的研究思路,为运动对肥胖症及代谢相关疾病的预防治疗提供潜在方法。With the deepening of research on the types,structures and biological functions of microRNAs( miRNAs),its role in the metabolic regulation of the body and the prevention and treatment of diseases have received extensive attention. As an important regulator of biological processes,miRNAs have become a research hotspot in the regulation of lipid metabolism biological processes in recent years,especially in the regulation of white and brown fat cell differentiation and browning,which is a new research target. In this paper,we review the positive and negative regulation of miRNAs on white fat browning and the effects of exercise on miRNAs and white fat browning,explore the mechanism and physiological significance of miRNAs on white fat browning,and prospect white fat browning. The purpose is to provide experimental researchers with new research ideas and provide potential methods for the prevention and treatment of obesity and metabolic related diseases.

关 键 词：MIRNAS 白色脂肪 棕色脂肪 白色脂肪棕 运动 

分 类 号：G804.5[文化科学—运动人体科学]