糖皮质激素联合依诺肝素钠对复发性早期流产患者BA、LP、AIA、ADPN影响  

Effects of glucocorticoid combined with enoxaparin sodium for treating patients with recurrent early abortion on their blocking antibody,leptin,anti-specific antibody,and adiponectin levels

作　　者：徐艳[1] 孙颖[1] 张晓珺 XU Yan;SUN Ying;ZHANG Xiaojun(Qingdao Municipal Hospital, Qingdao, Shandong Province, 266000)

机构地区：[1]青岛市市立医院,266000

出　　处：《中国计划生育学杂志》2021年第8期1574-1577,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨糖皮质激素联合依诺肝素钠治疗复发性早期流产效果及对患者封闭抗体(BA)、瘦素(LP)、抗独特性抗体(AIA)、脂联素(ADPN)作用。方法:选择2018年3月-2020年3月在本院接受治疗的复发性早期流产患者115例,随机数表法分为联合组(n=58)和单药组(n=57)。单药组给予依诺肝素钠治疗,联合组给予糖皮质激素联合依诺肝素钠治疗。比较两组临床疗效、血清BA、LP、AIA、ADPN、孕酮(P)、雌二醇(E2)、绒毛膜促性腺激素(β-hCG)水平变化情况、妊娠结局及不良反应。结果:治疗后联合组总有效率(91.4%)高于单药组(71.9%),两组BA、AIA转阳率均提高且联合组(87.9%、79.3%)高于单药组(64.9%、54.4%)(均P<0.05);血清激素LP、ADPN、P、E2、β-hCG两组均高于治疗前且联合组高于单药组(P<0.05)。联合组成功分娩率(87.9%)高于单药组(66.7%),异位妊娠(1.7%)、再次流产率(0)低于单药组(15.8%、8.8%)(P<0.05);两组不良反应总发生率(3.5%、7.0%)无差异(P>0.05)。结论:复发性早期流产患者应用糖皮质激素联合依诺肝素钠治疗可提高疗效,可能与其可有效改善患者BA、LP、AIA、ADPN水平有关。Objective:To study the effects of glucocorticoid combined with enoxaparin sodium for treating patients with recurrent early abortion on their blocking antibody(BA),leptin(LP),anti-specific antibody(AIA),and adiponectin(ADPN)levels.Methods:115 patients with recurrent early abortion were selected and were divided into group A and group B(n=57)by random number table method from March 2018 to March 2020.57 patients in group B were treated with enoxaparin sodium alone,and 58 patients in group A were treated with glucocorticoid combined with enoxaparin sodium.Clinical efficacy,the levels of serum BA,LP,AIA,ADPN,progesterone(P),estradiol(E2),and chorionic gonadotropin(β-hCG),pregnancy outcomes,and the incidence of adverse reaction of the patients were compared between the two groups.Results:After treatment,the total effective rate(91.4%)of the patients in group A was siginificant higher than that(71.9%)of the patients in group B.The positive conversion rates of BA and AIA of the patients in the two groups had increased siginificantly,and which(87.9%and 79.3%)of the patients in group A were siginificant higher than those(64.9%and 54.4%)of the patients in group B(all P<0.05).The levels of serum LP,ADPN,P,E2,andβ-hCG of the patients in the two groups were siginificant higher than those before treatment,and which of the patients in group A were siginificant higher than those of the patients in group B(P<0.05).The rate of successful delivery(87.9%)of the patients in group A was siginificant higher than that(66.7%)of the patients in group B,but the rates of ectopic pregnancy(1.7%)and abortion again(0%)of the patients in group A were siginificant lower than those(15.8%and 8.8%)of the patients in group B(P<0.05).There was no siginificant difference in the total incidence of adverse reactions(3.5%vs.7.0%)of the patients between the two groups(P>0.05).Conclusion:Glucocorticoid combined with enoxaparin sodium for treating patients with recurrent early abortion can improve the curative effect,which may be related to the effective

关 键 词：复发性早期流产 糖皮质激素 依诺肝素钠 封闭抗体 瘦素 抗独特性抗体 脂联素 

分 类 号：R71[医药卫生—妇产科学]