妊娠期糖尿病孕妇血清PLGF、TPOAb、HbA1c水平与母婴结局  

Correlation between the levels of serum placenta growth factor,thyroid peroxidase antibody,and hemoglobin 1c of pregnant women with gestational diabetes mellitus and their maternal and infant outcomes

作　　者：肖进 李国敏 田倩 XIAO Jin;LI Guomin;TIAN Qian(Liangshan Yi Autonomous Prefecture Hospital of Integrated Traditional Chinese and Western Medicine, Sichuan Province, 615000)

机构地区：[1]四川省凉山彝族自治州中西医结合医院,西昌615000

出　　处：《中国计划生育学杂志》2021年第8期1627-1631,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨妊娠期糖尿病孕妇血清胎盘生长因子(PLGF)、甲状腺过氧化物酶抗体(TPOAb)、血红蛋白1c(HbA1c)水平与母婴结局关系。方法:选取2018年1月-2020年3月本院收治的妊娠期糖尿病患者55例为观察组,同期规律产前检查健康孕妇55例为对照组。比较两组孕妇血清PLGF、TPOAb及HbA1c水平及母婴结局情况,logistic多因素逐步回归分析血清PLGF、TPOAb及HbA1c水平与母婴结局相关性。结果;观察组血清PLGF(58.78±10.27 pg/ml)低于对照组,TPOAb(46.37±8.87 U/ml)、HbA1c(5.77±1.02)%均高于对照组,TPOAb阳性率(30.9%)高于对照组(均P<0.05)。观察组不良母婴结局发生率(25.5%)高于对照组(9.1%)(P<0.05)。母婴结局不良孕妇血清PLGF水平低于正常孕妇,血清TPOAb、HbA1c水平、TPOAb阳性率均高于正常孕妇(P<0.05)。PLGF降低、TPOAb升高、HbA1c升高是妊娠期糖尿病患者不良母婴结局的危险因素(P<0.05)。结论:妊娠期糖尿病孕妇血清TPOAb、HbA1c水平高于健康孕妇,血清PLGF水平低于健康孕妇,血清PLGF、TPOAb及HbA1c水平与不良母婴结局有显著相关性。Objective:To investigate the relationship between the levels of serum placenta growth factor(PLGF),thyroid peroxidase antibody(TPOAb),and hemoglobin 1c(HbA1c)of pregnant women with gestational diabetes mellitus(GDM)and their maternal and infant outcomes.Methods:55 pregnant women with GDM were selected in observation group,and 55 healthy pregnant women were selected in control group from January 2018 to March 2020.The serum levels of PLGF,TPOAb,and HbA1c,and the maternal and infant outcomes of the women were compared between the two groups.Logistic stepwise regression was used to analyze the relationship between the levels of serum PLGF,TPOAb,and HbA1c of the women and their adverse maternal and infant outcomes.Results:The levels of serum PLGF(58.78±10.27 pg/ml),TPOAb(46.37±8.87 U/ml),and HbA1c(5.77±1.02%)of the women in the observation group were significant lower than those of the women in the control group,but the positive rate of TPOAb(30.9%)of the women in the observation group was significant higher than that of the women in the control group(all P<0.05).The incidence of adverse maternal and infant outcomes(25.5%)of the women in the observation group was significant higher than that(9.1%)of the women in the control group(P<0.05).The serum PLGF level of pregnant women with adverse maternal and infant outcomes was significant lower than that of normal pregnant women,but the serum TPOAb and HbA1c levels and the positive rate of TPOAb of pregnant women with adverse maternal and infant outcomes were significant higher(P<0.05).The decrease of PLGF level and the increase of TPOAb and HbA1c levels were the risk factors of adverse maternal and infant outcomes of pregnant women with GDM(P<0.05).Conclusion:The serum levels of TPOAb and HbA1c of pregnant women with GDM are significant higher than those of healthy women,but their serum level of PLGF was significant lower.The serum levels of PLGF,TPOAb,and HbA1c of pregnant women with GDM are significantly correlated with their adverse maternal and infant outcomes.

关 键 词：妊娠期糖尿病 胎盘生长因子 甲状腺过氧化物酶抗体 血红蛋白1c 母婴结局 相关性 

分 类 号：R71[医药卫生—妇产科学]