孕妇血清游离β-hCG及uE_(2)水平对妊娠期并发症及妊娠结局影响  

Correlation between the maternal serum freeβ-hCG and uE_(2) levels of pregnant women and their pregnancy complications and its influence on the pregnancy outcomes

作　　者：曾成碧 颜璐 雷娇 朱薇 ZENG Chengbi;YAN Lu;LEI Jiao;ZHU Wei(Guang'an People's Hospital, Guang'an, Sichuan Province, 638500;The Seventh People's Hospital of Chengdu)

机构地区：[1]四川省广安市人民医院,638500 [2]四川省成都市第七人民医院

出　　处：《中国计划生育学杂志》2021年第8期1714-1717,共4页Chinese Journal of Family Planning

摘　　要：目的:探究孕中期血清游离β-人绒毛膜促性腺激素(β-hCG)及尿雌二醇(uE2)水平对妊娠期并发症及妊娠结局影响。方法:回顾性分析2018年1月-2020年2月于本院产前检查并顺利分娩的200例孕妇临床资料,检测孕中期母体血清游离β-hCG及uE2水平,根据两种指标水平分组,分析不同水平孕妇妊娠期并发症及妊娠结局差异。结果:血清β-hCG升高组(>2.0MoM)妊娠期高血压、妊娠期糖尿病、胎盘早剥、胎膜早破及胎儿窘迫发生率均高于血清β-hCG正常组(0.5~2.0MoM)和血清β-hCG降低组(<0.5MoM)(P<0.05),而后两组无差异(P>0.05)。uE2降低组(<0.7MoM)妊娠期高血压、胎盘早剥、胎膜早破及胎儿窘迫发生率均高于uE2正常组(≥0.7MoM)(P<0.05)。Spearman相关分析显示,血清β-hCG高水平及uE2低水平均与妊娠期高血压、妊娠期糖尿病、胎儿窘迫、胎膜早破及胎盘早剥呈正相关性(P<0.05)。结论:血清β-hCG高水平和uE2低水平与妊娠期并发症和妊娠结局有关,提示孕中期检测孕妇两项指标对预防妊娠期并发症和不良妊娠结局有指导意义。Objective:To study the correlation between the maternal serum freeβ-human chorionic gonadotropin(β-hCG)and urine estradiol(uE2)levels of pregnant women and their pregnancy complications,and to analyze its influence on the pregnancy outcomes of the women.Methods:The clinical data of 200 pregnant women who had completed prenatal examinations and delivered successfully between January 2018 and February 2020 were analyzed retrospectively.The maternal serum freeβ-hCG and uE2 levels of the women during the second trimester of pregnancy were detected.And then,according to the freeβ-hCG and uE2 levels,these women were divided into different groups.The differences of pregnancy complications and pregnancy outcomes of the women in these different groups were analyzed.Results:The incidences of gestational hypertension,gestational diabetes,placental abruption,premature rupture of membranes,and fetal distress of the women withβ-hCG>2.0MoM were significant higher than those of the women withβ-hCG 0.5-2.0MoM and those of the women withβ-hCG<0.5MoM(P<0.05),but which had no statistically significant different between the women withβ-hCG 0.5-2.0MoM and the women withβ-hCG<0.5MoM(P>0.05).The incidences of gestational hypertension,placental abruption,premature rupture of membranes,and fetal distress of the women with serum uE2<0.7MoM were significant higher than those of the women with serum uE2≥0.7MoM(P<0.05).Spearman correlation analysis showed that the high-level of serumβ-hCG and the low-level of serum uE2 of the pregnant women were positively correlated with the incidences of their gestational hypertension,gestational diabetes,fetal distress,premature rupture of membranes,and placental abruption(P<0.05).Conclusion:The high-level of serumβ-hCG and the low-level of serum uE2 of the pregnant women are closely related to their pregnancy complications and pregnancy outcomes.It is suggested that the detections of serumβ-hCG and uE2 levels of the pregnant women during the second trimester of pregnancy have positive signif

关 键 词：孕中期 母体血清游离β-人绒毛膜促性腺激素 尿雌二醇 妊娠期并发症 妊娠结局 相关性 

分 类 号：R714.2[医药卫生—妇产科学]