自拟中药方剂联合激素补充疗法治疗下丘脑-垂体性闭经疗效  

Therapeutic effect of traditional Chinese medicine prescription combined with hormone replacement for treating women with hypothalamic-pituitary amenorrhea

作　　者：申友奎[1] 王雁秋 张玲云 SHEN Youkui;WANG Yanqiu;ZHANG Lingyun(Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang Province, 310007)

机构地区：[1]浙江省杭州市中医院,310007

出　　处：《中国计划生育学杂志》2021年第9期1815-1818,共4页Chinese Journal of Family Planning

摘　　要：目的:探究自拟中药方剂联合激素补充疗法治疗下丘脑-垂体性闭经的临床疗效。方法:选取2016年1月—2020年1月本院收治的66例下丘脑-垂体性闭经患者,随机数字表法分为观察组和对照组各33例。对照组采用单纯激素补充治疗,观察组在对照组基础上联合自拟中药方剂治疗。观察两组患者治疗前后性激素黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)水平、基础体温改善状况及临床疗效。结果:治疗后两组LH、FSH及E2水平均高于治疗前且观察组高于对照组,两组基础体温高低温差值和上升速度均高于治疗前且观察组变化幅度高于对照组,治疗总有效率观察组(87.9%)高于对照组(60.6%)(均P<0.05)。结论:应用中药辨证方剂煎服联合外源性激素补充疗法可有效改善下丘脑-垂体性闭经患者性激素水平及临床症状,治疗效果更佳。Objective:To explore the clinical effect of self-made Chinese medicine prescription combined with hormone replacement for treating women with hypothalamic-pituitary amenorrhea.Methods:A total of 66 women with hypothalamic-pituitary amenorrhea were selected and randomly divided into observation group and control group(33 cases in each group)according to the random number table from January 2016 to January 2020.The women in the control group were treated with gonadotrophin supplementation only,and the women in the observation group were additionally treated with self-made Chinese medicine prescription.The levels of sex hormones,such as luteinizing hormone(LH),follicle-stimulating hormone(FSH),and estradiol(E2)before and after treatment,and the improvement of basal body temperature and the clinical effects after treatment of the women in the two groups were observed.Results:After treatment,the LH,FSH,and E2 levels of the women in the two groups had increased significantly,and which of the women in the observation group were significant higher than those of the women in the control group.The difference value of high to low basal body temperature,and variations degree of the temperature rising of the women in the two groups had increased significantly after treatment,and which of the women in the observation group were significant higher than those of the women in the control group.The total effective rate(87.9%)of the women in the observation group was significant higher than that(60.6%)of the women in the control group(all P<0.05).Conclusion:The application of traditional Chinese medicine decoction combined with exogenous sex hormone supplement therapy can effectively improve the sex hormone levels and clinical symptoms of the women with hypothalamic-pituitary amenorrhea,which has better curative effect.

关 键 词：下丘脑-垂体性闭经 激素补充疗法 自拟中药方剂 性激素 基础体温 临床疗效 

分 类 号：R71[医药卫生—妇产科学]