枸橼酸氯米芬联合小剂量阿司匹林治疗PCOS不孕症及对miR-224、miR-206影响  

Effect of clomiphene citrate combined with low-dose aspirin for improving the symptoms of infertility women with polycystic ovary syndrome and its influence on the levels of miR-224 and miR-206 expression

作　　者：谭雪梅 赵敏 匡军 TAN Xuemei;ZHAO Min;KUANG Jun(Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei Province, 445000)

机构地区：[1]湖北省恩施土家族苗族自治州中心医院,445000

出　　处：《中国计划生育学杂志》2021年第9期1840-1844,共5页Chinese Journal of Family Planning

摘　　要：目的:观察枸橼酸氯米芬联合小剂量阿司匹林对多囊卵巢综合征(PCOS)不孕症症状改善和微小核苷酸224(miR-224)、微小核苷酸206(miR-206)表达的影响。方法:以2017年2月—2018年12月本院治疗的PCOS不孕症120例,随机数字法分为观察组及对照组各60例,两组均在月经第5天采取枸橼酸氯米芬治疗,观察组在此基础上联合小剂量阿司匹林治疗,直至排卵当日停药。两组均治疗3个月经周期。比较两组治疗效果、性激素水平、卵泡、内膜变化、卵巢血流情况、miR-224、miR-206及不良反应。结果:治疗后观察组妊娠率(61.7%)及排卵率(78.3%)均高于对照组(43.3%、61.7%)(P<0.05);两组优势卵泡数、子宫内膜增生厚度以及宫颈黏液评分均升高且观察组高于对照组,两组卵泡刺激素、雌二醇、黄体生成素均下降且观察组低于对照组,两组卵巢血流指标最大流速、阻力指数均显著改善,且观察组改善程度优于对照组,两组miR-224、miR-206下降且观察组低于对照组(均P<0.05);两组不良反应发生率无差异(P>0.05)。结论:PCOS不孕症患者采用枸橼酸氯米芬联合小剂量阿司匹林治疗,可使性激素水平下降,miR-224、miR-206降低,提高治疗效果。安全性较好。Objective:To study the effect of clomiphene citrate combined with low-dose aspirin for improving the symptoms of infertility women with polycystic ovary syndrome(PCOS),and to study its influence on the levels of miR-224 and miR-206 expression of the women.Methods:120 infertility women with PCOS were included as the research objects and were randomly divided into two groups by random number method from February 2017 to December 2018.The women in the two groups were treated with clomiphene citrate from the fifth day of menstruation to the day of ovulation for 3 menstrual cycles.The women in the observation group were given low-dose aspirin additionally.The treatment effect,the sex hormone levels,the follicular and endometrial changes,the ovarian blood flow situation,the serum mir-224 and miR-206 levels,and the adverse reactions rate of the women were compared between the two groups.Results:After treatment,the pregnancy rate(61.7%)and the ovulation rate(78.3%)of the women in the observation group were significant higher than those(43.3%and 61.7%)of the women in the control group(P<0.05).After treatment,the dominant follicle number,the thickness of endometrial hyperplasia,and the cervical mucus score of the women in the two groups had increased significantly,and those of the women in the observation group were significant higher than those of the women in the control group.The levels of follicle-stimulating hormone,estradiol,luteinizing hormone of the women in the two groups had decreased significantly,and those of the women in the observation group were significant lower than those of the women in the control group.The values of the maximum velocity and resistance index of ovary blood flow index of the women in the two groups had improved significantly,and the improved degree of which of the women in the observation group were significant better than those of the women in the control group.The levels of Mir-224 and Mir-206 had decreased significantly,and which of the women in the observation group were significant l

关 键 词：多囊卵巢综合征 不孕症 枸橼酸氯米芬 阿司匹林 治疗效果 

分 类 号：R71[医药卫生—妇产科学]