MiR-146a、sLOX-1、HCY诊断妊娠期高血压疾病合并肾功能损害效果  

Effect of miR-146a,sLOX-1,and HCY of pregnant women for diagnosing their pregnancy-induced hypertension and renal dysfunction

作　　者：郭陆晋 李逸群 郑晖 张家荣 GUO Lujin;LI Yiqun;ZHENG Hui;ZHANG Jiarong(Dingxi People's Hospital, Gansu Province, 743000)

机构地区：[1]甘肃省定西市人民医院,743000

出　　处：《中国计划生育学杂志》2021年第9期1907-1910,1915,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨miR 146a、可溶性凝集素样氧化型低密度脂蛋白受体1(sLOX 1)和同型半胱氨酸(HCY)诊断妊娠期高血压疾病合并肾功能损害价值。方法:选取2018年5月—2020年6月本院收治的119例妊娠孕妇临床资料,妊娠高血压疾病为观察组(n=69)、正常妊娠为对照组(n=50),根据观察组病情分为妊娠期高血压组(n=25)、子痫前期轻度组(n=25)、子痫前期重度组(n=19);肌酐清除率(Ccr)分为Ccr<80ml/min组(n=35)与Ccr≥80ml/min组(n=34)。结果:miR 146a、sLOX 1、HCY水平,观察组高于对照组,子痫前期重度组高于子痫前期轻度组和妊娠期高血压组,Ccr<80ml/min组高于Ccr≥80ml/min组(均P<0.05)。Spearman相关性分析显示,miR 146a、sLOX 1、HCY与妊娠期高血压疾病严重程度呈正相关,miR 146a、sLOX 1与HCY呈正相关(均P<0.05)。ROC曲线分析显示,miR 146a、sLOX 1、HCY及3项联合诊断妊娠期高血压患者并发肾功能损害的AUC分别为0.908、0.950、0.916、0.962(P<0.05),敏感度分别为88.6%、91.4%、82.9%、88.6%,特异度分别为85.3%、97.1%、94.1%、100.0%。结论:miR 146a、sLOX 1、HCY参与了妊娠期高血压疾病的发生发展,3指标联合检测对预测妊娠期高血压疾病患者肾功能损伤效能最佳。Objective:To explore the application value of miR-146a,soluble lectin-like oxidized low-density lipoprotein receptor-1(sLOX-1),and homocysteine(HCY)of pregnant women for diagnosing their pregnancy-induced hypertension and renal dysfunction.Methods:The clinical data of 119 pregnant women from May 2018 to June 2020 were selected for retrospective analysis.These women were divided into observation group(n=69)and control group(n=50)according to the presence or absence of pregnancy-induced hypertension.In the observation group,the women were divided into group A(25 women with pregnancy-induced hypertension),group B(25 women with mild preeclampsia),and group C(19 women with severe preeclampsia)according to the severity of pregnancy-induced hypertension.According to the creatinine clearance rate(Ccr),the women in the observation group were also divided into group D(35 women with Ccr<80ml/min)and group E(34 women with Ccr≥80ml/min).Results:The levels of Mir-146a,SLOx-1,and HCY of the women in the observation group were significant higher than those of the women in the control group,which of the women in group C were significant higher than those of the women in groups B and A,and which of the women in group C were significant higher than those of the women in group E(all P<0.05).Spearman correlation analysis showed that the levels of Mir-146a,Slox-1,and HCY of the women were positively correlated with the severity of their pregnancy-induced hypertension,and mir-146a and Slox-1 levels of the women were positively correlated with their HCY level(all P<0.05).ROC curve analysis showed that the AUC of Mir-146a level,SLOx-1 level,HCY level,and the combined of the levels of Mir-146a,SLOx-1,and HCY for diagnosing the renal function impairment of the women with pregnancy-induced hypertension were 0.908,0.950,0.916,and 0.962,respectively(P<0.05),which sensitivity were 88.6%,91.4%,82.9%,and 88.6%,respectively,and which specificity were 85.3%,97.1%,94.1%,and 100.0%,respectively.Conclusion:MiR-146a,sLOX-1,and HCY of the pregnant wo

关 键 词：妊娠期高血压疾病 肾功能损害:微小核酸146a 可溶性凝集素样氧化型低密度脂蛋白受体1 同型半胱氨酸 肌酐清除率 诊断效能 

分 类 号：R714.246[医药卫生—妇产科学] R714.258[医药卫生—临床医学]