SOCS3、LXRα、PLGF在妊娠高血压合并子痫前期中变化及其预测价值  

Changes of the levels of negative regulator of cytokine signaling 3,liver X receptorα,vascular placenta growth factor of pregnant women with pregnancy-induced hypertension and preeclampsia,and which predictive value for preeclampsia

作　　者：金朝[1] 林洁[1] 满琴 胡常军 张兰 詹霞[1] JIN Chao;LIN Jin;MAN Qin;HU Changjun;ZHANG Lan;ZHAN Xia(Zigong Maternal and Child Health Care Hospital, Zigong, Sichuan Province, 643000)

机构地区：[1]四川省自贡市妇幼保健院,643000

出　　处：《中国计划生育学杂志》2021年第9期1935-1938,共4页Chinese Journal of Family Planning

基　　金：四川省自贡市科技计划项目(2019YLSF14)。

摘　　要：目的:探讨细胞因子信号转导负调控因子3(SOCS3)、肝X受体α(LXRα)、血管胎盘生长因子(PLGF)在妊娠高血压合并子痫前期中变化及其预测价值。方法:前瞻性选取本院2016年1月—2019年12月收治的120例妊娠高血压合并子痫前期患者作为病例组,118例正常妊娠者为对照组,酶联免疫吸附法测定两组患者血清SOCS3、LXRα、PLGF表水平,采用logistic回归模型结合受试者工作特征曲线(ROC)评价各指标对妊娠高血压合并子痫前期诊断价值。结果:病例组血清SOCS3、PLGF水平低于对照组,LXRα高于对照组(P<0.001)。ROC曲线分析显示,截断值时分别为SOCS30.32ng/L、LXRα178.26ng/L、PLGF 41.56pg/ml时诊断子痫前期有一定诊断价值,而3指标联合检测可提高诊断效能(P<0.05),其诊断灵敏度81.7%、特异度70.3%,约登指数0.520,ROC曲线下面积为0.895(95%CI:0.811~0.947)。结论:妊娠高血压合并子痫前期患者血清LXRα表达异常升高,PLGF、SOCS3异常降低,3项指标联合检测诊断效能较好。Objective:To explore the changes of the levels of negative regulator of cytokine signaling 3(SOCS3),liver X receptorα(LXRα),vascular placenta growth factor(PLGF)of pregnant women with pregnancy-induced hypertension and preeclampsia,and to analyse their predictive value for preeclampsia.Methods:A prospective study design was conducted.120 pregnant women patients with pregnancy-induced hypertension and preeclampsia were selected in study group from January 2016 to December 2019,and 118 normal pregnant women were selected in control group during the same period.Enzyme-linked immunosorbent assay(ELISA)was used to detected the expression levels of serum SOCS3,LXRα,and PLGF of the women.Logistic regression model combined with receiver operating characteristic(ROC)curve was used to evaluate the values of the expression levels of serum SOCS3,LXRα,and PLGF for diagnosing pregnancy-induced hypertension and preeclampsia.Results:The levels of serum SOCS3 and PLGF of the women in the study group were significant lower than those of the women in the control group,but the LXRαlevel of the women in the study group was significant higher(P<0.001).ROC curve analysis showed that when the cutoff value of SOCS3 level,LXRαlevel,and PLGF level were 0.32 ng/L,178.26 ng/L,and 41.56 pg/ml,the levels of SOCS3,LXRα,and PLGF had some diagnostic value for preeclampsia.The combination detections of the levels of SOCS3,LXRα,and PLGF could improve the diagnostic efficiency(P<0.05),which sensitivity,specificity,and Youden index were 70.3%,81.7%,and 0.520,and which area under the ROC curve was 0.895(95%CI:0.811-0.947).Conclusion:The serum LXRαexpression of the pregnant women with pregnancy-induced hypertension and preeclampsia increases abnormally,and their serum PLGF and SOCS3 expression levels decrease abnormally.The combination detections of the levels of SOCS3,LXRα,and PLGF can improve the diagnostic efficiency.

关 键 词：妊娠高血压 子痫前期 细胞因子信号转导负调控因子3 肝X受体Α 腺苷A1受体 诊断价值 

分 类 号：R714.244[医药卫生—妇产科学] R714.246[医药卫生—临床医学]