肥胖型多囊卵巢综合征患者血清RBP-4、IL-1β、VEGF相关性及临床意义  

The correlation and clinical significance of retinol binding protein-4,interleukin-1β,and vascular endothelial growth factor expressions of obesity women with polycystic ovarian syndrome

作　　者：贾奕娟 王中显 吴春林[1] 王冬花[1] JIA Yijuan;WANG Zhongxian;WU Chunlin;WANG Donghua(The First Hospital of Wuhan, Wuhan, Hubei Province, 430022)

机构地区：[1]湖北省武汉市第一医院,430022

出　　处：《中国计划生育学杂志》2021年第9期1960-1962,共3页Chinese Journal of Family Planning

摘　　要：目的:探究血清视黄醇结合蛋白-4(RBP-4)、白细胞介素(IL)-1β与血管内皮生长因子(VEGF)表达水平在肥胖型多囊卵巢综合征(PCOS)临床意义。方法:选择2017年1月—2020年4月于本院确诊PCOS且肥胖(体质指数≥28kg/m^(2))患者80例为PCOS组,同期体检、年龄相似肥胖女性80例为对照组。收集各组静脉血,分析RBP-4、IL-1β、VEGF水平。结果:PCOS组比对照组血清RBP-4(35.1±6.5μg/ml比27.4±3.5μg/ml)、IL-1β(11.9±3.4pg/ml比8.6±1.9 pg/ml)、VEGF(553.3±58.6 ng/ml比412.5±76.2ng/ml)均高,且PCOS组中排卵功能障碍患者上述3项指标均高于无障碍患者(均P<0.05)。PCOS组RPB-4、IL-1β、VEGF间均呈正相关(均P<0.05)。结论:RPB-4、IL-1β、VEGF通过调节炎症反应、甘油三脂代谢、血管生成增加排卵功能障碍的风险,参与了PCOS的发生发展。Objective:To explore the clinical significance of retinol binding protein-4(RBP-4),interleukin-1β(IL-1β),and vascular endothelial growth factor(VEGF)expressions of obesity women with polycystic ovarian syndrome(PCOS).Methods:80 obesity(body mass index≥28kg/m2)women with PCOS were selected in observation group and 80 obesity women without PCOS who had the same age were selected in control group from January 2017 to April 2020.The venous bloods of the women in the two groups were collected for analyzing the expression levels of serum RBP-4,IL-1βand VEGF.Results:The levels of RBP-4(35.1±6.5μg/ml),IL-1β(11.9±3.4pg/ml),and VEGF(553.3±58.6 ng/ml)of the women in the observation group were significant higher than those(27.4±3.5μg/ml,8.6±1.9 pg/ml,and 412.5±76.2ng/ml)of the women in the control group,and which of the women with ovulation dysfunction in the observation group were significant higher than those of the women without ovulation dysfunction(all P<0.05).The RPB-4 level,IL-1βlevel,and VEGF3 level of the women in the observation group were positive correlation each other(all P<0.05).Conclusion:RPB-4,IL-1βand VEGF maybe involve in the occurrence and development of PCOS by regulating the inflammatory response,the triglyceride metabolism,and the risk of ovulatory dysfunction increased by angiogenesis.

关 键 词：多囊卵巢综合征 肥胖 视黄醇结合蛋白-4 白细胞介素-1Β 血管内皮生长因子 相关性 

分 类 号：R711.75[医药卫生—妇产科学]