块诺酮片辅治绝经过渡期功能性子宫出血疗效及对子宫内膜厚度的影响评价  

Evaluation of the effect of Norethinnes tablets in the Treatment of Functional uterine bleeding during Menopausal transition and its Influence on Endometrial thickness

作　　者：吴皖珂 吴江平[1] 孔晶 Wu Wdnke;Wu Jiangping;Kong Jing(Department of Women's Health,Nanjing Maternity Hospital,Nanjing Medical University/Nanjing Maternal and Child Health Hospital,Nanjing 210000,China)

机构地区：[1]南京医科大学附属妇产医院/南京市妇幼保健院妇女保健科,江苏南京210000

出　　处：《实用妇科内分泌电子杂志》2021年第10期55-58,共4页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的评价烘诺酮片辅治绝经过渡期功能性子宫出血(绝经过渡期功血)的临床疗效及对子宫内膜厚度的影响。方法选取60例绝经过渡期功血患者,根据治疗方法不同分为对照组与研究组,每组30例。对照组采用氨甲环酸片(妥赛敏)治疗,研究组采用烘诺酮片辅助治疗。对比两组相关指标、治疗前后子宫内膜厚度、临床疗效及不良反应发生情况。结果研究组出血量明显少于对照组,出血明显减少时间及完全止血时间均明显短于对照组,差异具有统计学意义(P<0.05)。治疗前,两组子宫内膜厚度对比,差异无统计学意义(P>0.05);治疗后,研究组子宫内膜厚度明显薄于对照组,差异有统计学意义(F<0.05)。研究组总有效率为96.67%,明显高于对照组的76.67%,差异有统计学意义(P<0.05)。研究组不良反应发生率为6.67%,明显低于对照组的26.67%,差异有统计学意义(P<0.05)。结论绝经过渡期功血患者采取烘诺酮片辅治可减少其出血量,缩短出血及止血时间,对患者子宫内膜厚度的影响较小,临床疗效及安全性较高。Objective To evaluate the clinical efficacy of norethinnes tablets in the treatment of menopausal transitional functional uterine bleeding(menopausal transitional functional blood)and the effect on endometrial thickness.Methods 60 cases of menopausal transition patients with functional blood were selected and divided into control group and study group according to different treatment methods,30 cases in each group.The control group was treated with tranexamic acid tablets(tosemiu),and the study group was treated with norethinnes tablets.The related indexes,endometrial thickness,clinical efficacy and the occurrence of adverse reactions were compared between the two groups.Results The amount of bleeding in the study group was significantly less than that in the control group,and the time of bleeding reduction and complete hemostasis were significantly shorter than that in the control group,with statistical significance(P<0.05).Before treatment,there was no significant difference in endometrial thickness between the two groups(P>0.05).After treatment,endometrial thickness in the study group was significantly thinner than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of the study group was 96.67%,which was significantly higher than that of the control group(76.67%),with statistical significance(P<0.05).The incidence of adverse reactions in the study group was 6.67%,which was significantly lower than that in the control group(26.67%),with statistical significance(P<0.05).Conclusion Adjuvant treatment with norethinnes tablets can reduce the amount of bleeding,shorten the time of bleeding and hemostasis,and has little effect on endometrial thickness,with high clinical efficacy and safety.

关 键 词：绝经过渡期 功能性子宫出血 烘诺酮片 氨甲环酸片 

分 类 号：R711.52[医药卫生—妇产科学]