2019年东莞市厚街医院细菌耐药性监测分析  

Analysis of bacterial resistance surveillance in Dongguan Houjie hospital in 2019

作　　者：邓任堂[1] 孔桂兴[1] 赖丽莎 揭育帮 梁洁如 DENG Rentang;KONG Guixing;LAI Lisha;JIE Yubang;LIANG Jieru(Department of Clinical Laboratory,Dongguan Houjie Hospital,Dongguan,Guangdong 523945,China)

机构地区：[1]广东省东莞市厚街医院检验科,广东东莞523945

出　　处：《检验医学与临床》2021年第21期3132-3136,3140,共6页Laboratory Medicine and Clinic

摘　　要：目的了解2019年该院临床分离细菌对抗菌药物的耐药性。方法收集2019年该院临床分离的1220株非重复菌株,采用纸片扩散法或自动化仪器法进行药敏试验,按相关标准判读药敏结果,采用WHONET5.6软件进行数据分析。结果1220株细菌中,革兰阴性菌占72.1%,革兰阳性菌占27.9%。较常见的5种细菌分别为大肠埃希菌(34.1%)、肺炎克雷伯菌(10.7%)、金黄色葡萄球菌(10.2%)、铜绿假单胞菌(7.0%)和凝固酶阴性葡萄球菌(6.2%)。耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)的检出率分别为15.2%和65.8%。MRSA和MRCNS对各类抗菌药物的耐药率明显高于甲氧西林敏感金黄色葡萄球菌(MSSA)和甲氧西林敏感凝固酶阴性葡萄球菌(MSCNS)。未发现对万古霉素耐药的葡萄球菌。链球菌属细菌对红霉素、克林霉素耐药率高,未发现对万古霉素、青霉素耐药的菌株。产超广谱β-内酰胺酶的大肠埃希菌、肺炎克雷伯菌检出率分别为27.9%和26.9%。肠杆菌科细菌对碳青霉烯类抗菌药物最敏感,未发现耐药菌株。铜绿假单胞菌对亚胺培南和美罗培南的耐药率分别为8.4%和12.2%,对头孢吡肟的耐药率最低(0.0%)。结论细菌耐药性具有地域特点,定期进行细菌耐药性监测有助于了解该院细菌耐药性的变迁,为临床经验用药和合理用药提供依据。Objective To understand the resistance of bacteria isolated from the hospital in 2019 to antimicrobial drugs.Methods A total of 1220 non-repetitive strains isolated from the hospital in 2019 were collected,and the drug susceptibility test was carried out by the paper diffusion method or the automated instrument method.The drug susceptibility results were interpreted according to relevant standards,and the WHONET 5.6 software was used for data analysis.Results Among 1220 strains of bacteria,gram-negative bacteria accounted for 72.1%,and gram-positive bacteria accounted for 27.9%.The five most common bacteria were Escherichia coli(34.1%),Klebsiella pneumoniae(10.7%),Staphylococcus aureus(10.2%),Pseudomonas aeruginosa(7.0%)and coagulase-negative Staphylococcus(6.2%).The detection rates of methicillin-resistant Staphylococcus aureus(MRSA)and methicillin-resistant coagulase-negative Staphylococcus(MRCNS)were 15.2%and 65.8%,respectively.The resistance rates of MRSA and MRCNS strains to various antibacterial drugs were significantly higher than that of methicillin-sensitive Staphylococcus aureus(MSSA)and methicillin-sensitive coagulase-negative Staphylococcus(MSCNS).No Staphylococci resistant to vancomycin were found.Streptococcus bacteria had a high resistance rate to erythromycin,clindamycino and no strains resistant to vancomycin and penicillin had been found.The detection rates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrumβ-lactamase were 27.9%and 26.9%,respectively.Enterobacteriaceae bacteria were the most sensitive to carbapenem antibacterial drugs,no drug-resistant strains were found.The resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 8.4%and 12.2%,respectively,and the resistance rate to cefepime was the lowest(0.0%).Conclusion Bacterial drug resistance has regional characteristics.Regular monitoring of bacterial drug resistance is helpful to understand the changes of bacteria and drug resistance in the hospital,and provides a basis for clinical experience an

关 键 词：细菌耐药性监测 药敏试验 抗菌药物 

分 类 号：R446.5[医药卫生—诊断学]