种植体周围龈沟液中IL-6、CRP及氧化应激标志物水平与种植体周围炎的关系  

Relationship between the levels of IL-6,CRP and oxidative stress markers in gingival crevicular fluid around implants and peri-implant inflammation

作　　者：喻莉 许益萌 杨一帆 YU Li;XU Yimeng;YANG Yifan(Department of Stomatology,Affiliated Hospital of Northwest University/Xi′an Third Hospital,Xi′an,Shaanxi 710000,China;Department of Orthodontics,Affiliated Stomatological Hospital of Air Force Military Medical University,Xi′an,Shaanxi 710032,China)

机构地区：[1]西北大学附属医院/西安市第三医院口腔科,陕西西安710000 [2]空军军医大学附属口腔医院口腔正畸科,陕西西安710032

出　　处：《检验医学与临床》2021年第21期3153-3156,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨种植体周围龈沟液(PICF)中白细胞介素-6(IL-6)、C反应蛋白(CRP)及氧化应激标志物水平变化与种植体周围炎的关系。方法选取2018年10月至2020年10月西北大学附属医院口腔门诊实施种植修复的100例(141个种植牙位)患者为研究对象,其中32例(48个种植牙位)患者发生种植体周围炎(炎症组)、68例(93个种植牙位)患者为健康种植体(对照组)。检测两组PICF中IL-6、CRP、超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GP-Phx)水平,并分析上述指标与牙周探诊深度(PD)、菌斑指数(PLI)、龈沟出血指数(SBI)的关系。结果炎症组患者种植体的PD、PLI、SBI均明显高于对照组(P<0.05);炎症组患者PICF中IL-6、CRP水平均明显高于对照组(P<0.05),SOD、GP-Phx水平均明显低于对照组(P<0.05);炎症组患者种植体的PLI、PD、SBI与PICF中IL-6、CRP水平均呈正相关(P<0.05),与SOD、GP-Phx水平均呈负相关(P<0.05)。结论种植体的PICF中炎症指标及氧化应激标志物水平变化可反映炎症程度。Objective To investigate the relationship between the levels of interleukin-6(IL-6),C-reactive protein(CRP)and oxidative stress markers in gingival crevicular fluid around implants(PICF)and peri-implant inflammation.Methods From October 2018 to October 2020,100 patients(141 dental implant positions)who performed implant restorations in the dental clinic of the Affiliated Hospital of Northwest University were selected as the research objects,of which 32 cases(48 dental implant positions)had peri-implant inflammation(inflammation group),68 cases(93 implant positions)were healthy implants(control group).The levels of IL-6,CRP,superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione peroxidase(GP-Phx)in the two groups of PICF were detected.The relationship between the above indicators and probing depth(PD),plaque index(PLI),sulcus bleeding index(SBI)were analyzed.Results The PD,PLI,and SBI of implants in the inflammation group were significantly higher than those in the control group(P<0.05).The levels of IL-6 and CRP in PICF in the inflammation group were significantly higher than those in the control group(P<0.05),The levels of SOD,GP-Phx were significantly lower than the control group(P<0.05).The PLI,PD,SBI of the implants in the inflammation group were positively correlated with the levels of IL-6 and CRP in PICF(P<0.05),and negatively correlated with the levels of SOD and GP-Phx in PICF(P<0.05).Conclusion The changes in the levels of inflammation indicators and oxidative stress markers in the PICF of implants can reflect the degree of inflammation.

关 键 词：种植体周围龈沟液 白细胞介素-6 C反应蛋白 氧化应激 

分 类 号：R781.9[医药卫生—口腔医学]