阿托西班对瘢痕子宫不孕症患者解冻胚胎移植结局的影响  

Effect of atosiban on outcomes of frozen-thawed embryo transfer in infertile patients with scar uterus

作　　者：汪晶 邹慧娟 朱大敏 马聪 李丹阳 曹云霞[1,4,5] 许孝凤 Wang Jing;Zou Huijuan;Zhu Damin(Dept of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,Anhui Medical University,Hefei 230032;Key Laboratory of Population Health Across Life Cycle,Anhui Medical University,Ministry of Education of The People′s Republic of China,Hefei 230032;Anhui Province Key Laboratory of Reproductive Health and Genetics,Hefei 230032;Biopreservation and Artificial Organs,Anhui Provincial Engineering Research Center,Anhui Medical University,Hefei 230032;Dept of Obstetrics and Gynecology,The Affiliated Chaohu Hospital of Anhui Medical University,Chaohu 238001)

机构地区：[1]安徽医科大学第一附属医院妇产科,合肥230022 [2]国家卫生健康委配子及生殖道异常研究重点实验室,合肥230032 [3]出生人口健康教育部重点实验室,合肥230032 [4]生殖健康与遗传安徽省重点实验室,合肥230032 [5]安徽省生命资源保存与人工器官工程技术研究中心,合肥230032 [6]安徽医科大学附属巢湖医院妇产科,巢湖238001

出　　处：《安徽医科大学学报》2021年第10期1661-1664,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1908085MH244);中国医学科学院中央级公益性科研院所基本科研业务费专项资金(编号:2019PT310002)。

摘　　要：目的探讨瘢痕子宫不孕症患者在行解冻胚胎移植前使用阿托西班对其移植结局的影响。方法回顾性分析剖宫产瘢痕子宫的继发性不孕症患者278例,根据解冻移植前30 min内是否静脉注射小剂量阿托西班(6.75 mg/0.9 ml)分为观察组(128例)和对照组(150例),分别从整体和不同移植次数(1次、2次、≥3次)分层来比较观察组和对照组之间的胚胎种植率、生化妊娠率、临床妊娠率和活产率的差异。结果整体观察组的胚胎种植率、生化妊娠率、临床妊娠率和活产率均有改善,但差异无统计学意义(P>0.05);观察组中第2次移植的患者的移植结局改善较大,但差异无统计学意义(P>0.05)。结论解冻胚胎移植前注射阿托西班不能显著改善瘢痕子宫不孕症患者的移植结局。Objective To investigate the effect of atosiban on frozen-thawed embryo transfer outcomes in infertile patients with scar uterus.Methods This was a retrospective study.278 secondary infertile patients with cesarean scar uterus were divided into two groups,the study group(n=128)treated with low-dose atosiban(6.75 mg/0.9 ml,iv)within 30 min before fozen-thawed embryo transfer,while the control group(n=150)without treatment with atosiban.Then the two groups were respectively stratified according to the times of embryo transfer,which were the first time,second time and third time or more.The differences of embryo implantation rate,biochemical pregnancy rate,clinical pregnancy rate and live birth rate between study group and control group were compared.Results The embryo implantation rate,biochemical pregnancy rate,clinical pregnancy rate and live birth rate of the overall study group were improved,but the difference was not statistically significant(P>0.05);atosiban could greatly improve the transfer outcomes of patients in the second embryo transfer,but the difference was not statistically significant(P>0.05).Conclusion Treatment with atosiban before frozen-thawed embryo transfer can′t significantly improve transfer outcomes of infertile patients with scar uterus.

关 键 词：阿托西班 解冻胚胎移植 瘢痕子宫 移植结局 

分 类 号：R711.6[医药卫生—妇产科学]