仿生提取-电感耦合等离子体质谱法测定柏子养心丸中可溶性汞的含量  

Determination of Soluble Mercury in Baiziyangxin Pills by Bionic Extraction-ICP-MS

作　　者：丁银平 任琦 万林春 许妍 洪挺 DING Yin-ping;REN Qi;WAN Lin-chun;XU Yan;HONG Ting(Jiangxi Institute for Drug Control,NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine,Jiangxi Province Engineering Research Center of Drug and Medical Device Quality,Jiangxi Nanchang 330029,China)

机构地区：[1]江西省药品检验检测研究院,国家药品监督管理局中成药质量评价重点实验室,江西省药品与医疗器械质量工程技术研究中心,江西南昌330029

出　　处：《中国药物评价》2021年第5期383-386,共4页Chinese Journal of Drug Evaluation

基　　金：江西省食品药品监督管理局科研项目(项目名称:国家基本药物柏子养心丸质量风险管理新方法研究;项目编号:2017YX01)。

摘　　要：目的:建立仿生提取电感耦合等离子体质谱技术(ICP-MS)测定柏子养心丸中可溶性汞含量的分析方法。方法:通过模拟人体胃肠道环境,采用人工胃液提取柏子养心丸中的可溶性汞,结合ICP-MS进行分析测定。结果:可溶性汞质量浓度在0~8.0 ng·mL^(-1)范围内与测量值线性关系良好,平均加样回收率为96.36%,RSD为1.7%(n=6)。结论:通过对实际样品的测定,该方法可用于柏子养心丸中可溶性汞含量的测定。Objective:To establish a method for determination of the leachable mercury in Baiziyangxin Pills by bionic extraction-ICP-MS.Methods:Through simulating stomach condition,the leachable mercury was extracted by artificial gastric juice and detected by ICP-MS.Results:The linear range of soluble mercury was 0~8.0 ng·mL^(-1).The average recovery was 96.36%,RSD was 1.7%(n=6).Conclusion:The developed method is simple,sensitive,accurate,and it′s suitable for the determination of leachable mercury in Baiziyangxin Pills.

关 键 词：柏子养心丸 仿生提取 电感耦合等离子体质谱法 可溶性汞 含量 

分 类 号：R284.2[医药卫生—中药学]