胎儿纤维连接蛋白在孕晚期引产中的临床应用价值  

Clinical application value of fetal fibronectin in late pregnancy induced labor

作　　者：陈关凤 刘会芳[1] 刘颖菊 阮和云[1] Chen Guanfeng;Liu Huifang;Liu Yingju(Department of Obstetrics,Affiliated Ethnic Hospital of Guangxi Medical University,Nanning 530001)

机构地区：[1]广西医科大学附属民族医院产科,广西南宁530001

出　　处：《中国现代医药杂志》2021年第10期26-29,共4页Modern Medicine Journal of China

基　　金：广西崇左市科技计划项目(编号:崇科攻11031230)。

摘　　要：目的探讨胎儿纤维连接蛋白(fFN)水平在孕晚期引产中的临床应用价值。方法选取2019年1月~2020年1月我院孕晚期产妇92例为观察对象,检测fFN水平,fFN<50μg/L定义为阴性,fFN≥50μg/L定义为阳性;比较打水囊前后f FN阳性、fFN阴性产妇的宫颈成熟度评分、合并症、引产结局;比较fFN<50μg/L、50~2000μg/L、>2000μg/L的产妇引产结局;分析fFN水平对孕晚期引产结局的预测价值。结果打水囊后产妇阴道分泌物fFN阳性率、阴性率与打水囊前比较差异有统计学意义(P<0.05);打水囊前后fFN阳性、fFN阴性产妇之间宫颈成熟度评分、合并症和打水囊前相比差异无统计学意义(P>0.05),fFN阳性产妇的顺产率较高,剖宫产率较低(P<0.05);打水囊前,阴道分泌物f FN<50μg/L、50~2000μg/L、>2000μg/L的产妇顺产率、剖宫产率差异无统计学意义(P>0.05),打水囊后,随着产妇阴道分泌物fFN水平升高,顺产率升高,剖宫产率下降(P<0.05);与打水囊前比较,打水囊后阴道分泌物fFN水平预测孕晚期引产结局的特异度显著升高(P<0.05),敏感度、阳性预测值、阴性预测值无明显差异(P>0.05)。结论孕晚期引产中,打水囊后产妇阴道分泌物的fFN阳性率升高,阴性率下降,阴道分泌物的fFN水平对引产结局有一定的预测价值。Objective To investigate the clinical application value of fetal fibronectin(fFN)in late pregnancy induced labor.Methods From Jan 2019 to Jan 2020,92 women with late pregnancy in our hospital were selected as the observation objects,and fFN level was detected.fFN<50μg/L was defined as negative,fFN≥50μg/L was defined as positive.The Bishop score,complications and induced labor outcome of fFN positive and fFN negative parturients were compared before and after water sac injection.fFN<50μg/L,fFN 50~2000μg/L and fFN>2000μg/L maternal induced labor outcome were compared.Analyzed the predictive value of fFN level for the outcome of induced labor in late pregnancy.Results The fFN positive rate and negative rate of vaginal secretions were significantly different from those before water sac injection(P<0.05).There was no significant difference in Bishop score and complications between fFN positive and fFN negative women before and after water sac injection(P>0.05).fFN positive parturient had higher normal delivery rate and lower cesarean section rate(P<0.05).There was no significant difference in normal delivery rate and cesarean section rate among vaginal secretion fFN<50μg/L,50~2000μg/L and>2000μg/L before water sac injection(P>0.05).After water sac injection,with the increase of vaginal secretion fFN level,the normal delivery rate increased and the cesarean section rate decreased(P<0.05).Compared with before water sac injection,the specificity of fFN after water sac injection to predict the outcome of induced labor in late pregnancy was significantly increased(P<0.05).There were no significant differences in sensitivity,positive predictive value and negative predictive value(P>0.05).Conclusion In late pregnancy induced labor,the positive rate of fFN in matermal vaginal secretions increase and the negative rate decrease behind the water sac injection.fFN of vaginal secretions has a certain predictive value for the outcome of induced labor.

关 键 词：胎儿纤维连接蛋白 孕晚期 引产 预测 剖宫产 特异性 

分 类 号：R719.3[医药卫生—妇产科学]