Boosting the cellular potency of embryonic stem cells by spliceosome targeting  

作　　者：Wilfried A.Kues 

机构地区：[1]Friedrich-Loeffler-lnstitut,Federal Research Institute for Animal Health,Biotechnology,Stem Cell Physiology,Neustadt,Germany

出　　处：《Signal Transduction and Targeted Therapy》2021年第9期2613-2614,共2页信号转导与靶向治疗（英文）

摘　　要：In recent work published in Cell,Shen et al.1 identified spliceosome inhibition in embryonic stem(ES)cells as a key mechanism for the transition from pluri-to totipotency.Spliceosome inhibition,achieved by RNA interference or the chemical inhibitor pladienolide B,may gain widespread relevance to the culture of totipotent ES cells,in vitro differentiation of extra-embryonal tissue and organoids,translation to the maintenance of pluripotent cells of other mammal species,including humans,and a better molecular understanding of cellular potency in stem cells and cancer.

关 键 词：some CULTURE 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]