SARS-CoV-2-derived fusion inhibitor lipopeptides exhibit highly potent and broad-spectrum activity against divergent human coronaviruses  

作　　者：Yuanmei Zhu Danwei Yu Yue Hu Tong Wu Huihui Chong Yuxian He 

机构地区：[1]NHC Key Laboratory of Systems Biology of Pathogens,Institute of Pathogen Biology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第9期2615-2617,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the National Natural Science Foundation of China(81630061);the CAMS Innovation Fund for Medical Sciences(2017-I2M-1-014).

摘　　要：Dear Editor,Most members of coronaviruses(CoVs),including four annually circulating human CoVs(HCov-229E,HCoV-OC43,HCoV-NL63;and CoV-HKU1),infect the respiratory tract of mammals and cause mild illness;however,zoonotic CoVs can cross the species barrier from animal reservoirs and lead to epidemics with high morbidity and mortality in humans.

关 键 词：mortality respiratory annually 

分 类 号：R563.1[医药卫生—呼吸系统]