Decreased inhibition of exosomal miRNAs on SARS-CoV-2 replication underlies poor outcomes in elderly people and diabetic patients  

作　　者：Yanbo Wang Xiaoju Zhu Xia-Ming Jiang Jingwei Guo Zheng Fu Zhen Zhou Ping Yang Hongyuan Guo Xu Guo Gaoli Liang Ping Zeng Gengfu Xiao Jizheng Ma Xin Yin Lei-Ke Zhang Chao Yan Chen-Yu Zhang 

机构地区：[1]Nanjing Drum Tower Hospital Center of Molecular Diagnostic and Therapy,Chinese Academy of Medical Sciences Research Unit of Extracellular RNA,State Key Laboratory of Pharmaceutical Biotechnology,Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology,NJU Advanced Institute of Life Sciences(NAILS),NJU Institute of Al Biomedicine and Biotechnology,Chemistry and Biomedicine Innovation Center(ChemBIC),School of Life Sciences,Nanjing University,Nanjing,China [2]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,Hubei,China [3]Department of Clinical Laboratory,The Affiliated Drum Tower Hospital of Nanjing University Medical School,Nanjing,China [4]The MOH Key Laboratory of Geriatrics,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing,China [5]The Research Center of Military Exercise Science,The Army Engineering University of PLA,Nanjing,Jiangsu,China

出　　处：《Signal Transduction and Targeted Therapy》2021年第9期2822-2830,共9页信号转导与靶向治疗（英文）

基　　金：This work was supported by the Chinese Science and Technology Major Project of China(2015ZX09102023-003);National Basic Research Program of China(973 Program)(2014CB542300 and 2012CB517603);National Natural Science Foundation of China(81250044,81602697,32000549 and 31741075);Training Program of the Major Research Plan of the National Natural Science Foundation of China(92049109);the Natural Science Foundation of Jiangsu Province(BE2016737);the Fundamental Research Funds for the Central Universities(020814380146).

摘　　要：Elderly people and patients with comorbidities are at higher risk of COVID-19 infection,resulting in severe complications and high mortality.However,the underlying mechanisms are unclear.In this study,we investigate whether miRNAs in serum exosomes can exert antiviral functions and affect the response to COVID-19 in the elderly and people with diabetes.

关 键 词：patients MORTALITY INFECTION 

分 类 号：R563.1[医药卫生—呼吸系统] R587.1[医药卫生—内科学]